Factors associated with development of complications among adults with influenza: A 3-year prospective analysis
Journal
Journal of the Formosan Medical Association
Journal Volume
111
Journal Issue
7
Pages
364-369
Date Issued
2012
Author(s)
Abstract
Background/Purpose: This prospective study aimed to describe the clinical features, as well as outcomes, of adult patients with influenza of different severity, and to determine the predictors for development of complications. Methods: From December 2006 to March 2009, four types of diagnostic tests were given to both in- and outpatients with influenza-like illness (ILI). Confirmed cases were categorized into three groups (uncomplicated, moderately complicated, and severely complicated) for analysis using a proportional odds logistic regression model. Results: A total of 206 laboratory-confirmed cases of influenza were identified out of 360 enrolled patients with ILI. Among 30 patients (14.6%) classified as complicated cases due to development of pneumonia (n=28) and viral encephalopathy (n=2), 16 were hospitalized in general wards (moderately complicated) and 14 required admission to intensive care units (severely complicated). Complicated patients were less likely to have classic symptoms of ILI than uncomplicated patients. By multivariate analysis, the presence of coronary artery disease, systemic corticosteroid use, impaired renal function and delayed hospital visit were independently associated with development of complications. Conclusion: Our study results may help clinicians to identify patients at high risk for complicated influenza, to provide timely antiviral therapy and optimal clinical care. ? 2012.
SDGs
Other Subjects
antivirus agent; oseltamivir; adult; antiviral therapy; article; artificial ventilation; bloodstream infection; brain disease; brain infection; clinical feature; controlled clinical trial; controlled study; coronary artery disease; diagnostic test; disease course; disease severity; female; hospital patient; hospitalization; human; influenza; intensive care; kidney failure; length of stay; major clinical study; male; outpatient; pneumonia; prediction; shock; treatment outcome; Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Chi-Square Distribution; Coronary Artery Disease; Encephalitis, Viral; Female; Hospitalization; Humans; Influenza, Human; Kidney Diseases; Logistic Models; Male; Middle Aged; Multivariate Analysis; Pneumonia, Viral; Prospective Studies; Risk Factors; Taiwan; Young Adult
Type
journal article