Association between cytomegalovirus-specific reactivity of T cell subsets and development of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome
Journal
Journal of Infectious Diseases
Journal Volume
184
Journal Issue
11
Pages
1386-1391
Date Issued
2001
Author(s)
Abstract
The association between cytomegalovirus (CMV)-specific reactivity of T cell subsets and development of CMV retinitis (CMV-R) was prospectively studied in 50 CMV-seropositive AIDS patients. The frequency of CMV-specific CD69 expression on CD8 T cells was similar in patients with and patients without CMV-R (median, 1.0% vs. 1.2%; P = .14). However, the frequency of CMV-specific CD69 expression on CD4 T cells was significantly lower in patients with CMV-R than in those without CMV-R (median, 0.4% vs. 2.25%; P < .001). CMV-specific CD4 T cell reactivity in patients who developed CMV-R shortly after starting highly active antiretroviral therapy (HAART) remained low, although the CD4 cell counts increased markedly. Therefore, development of CMV-R is associated with a poor CMV-specific reactivity of CD4 T cells but not with poor reactivity of CD8 T cells. Development of CMV-R after initiation of HAART is associated with a poor reconstitution of CMV-specific immune response, rather than with immune rebound.
Other Subjects
CD4 antigen; CD69 antigen; CD8 antigen; acquired immune deficiency syndrome; adult; antigen expression; article; cellular immunity; clinical article; controlled study; Cytomegalovirus; disease activity; female; human; human cell; immunoreactivity; lymphocyte proliferation; male; priority journal; quantitative assay; retinitis; T lymphocyte; virus infection; Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Retinitis; Cytotoxicity Tests, Immunologic; Female; Humans; Interferon Type II; Lymphocyte Activation; Male; Prospective Studies; T-Lymphocyte Subsets; Time Factors
Type
journal article