https://scholars.lib.ntu.edu.tw/handle/123456789/516662
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | H-L Liu | en_US |
dc.contributor.author | H-Y Hsieh | en_US |
dc.contributor.author | L-A Lu | en_US |
dc.contributor.author | C-W Kang | en_US |
dc.contributor.author | M-F Wu | en_US |
dc.contributor.author | C-Y Lin | en_US |
dc.contributor.author | HAO-LI LIU | en_US |
dc.contributor.author | H-L Liu | zh-TW |
dc.contributor.author | H-Y Hsieh | zh-TW |
dc.contributor.author | L-A Lu | zh-TW |
dc.contributor.author | C-W Kang | zh-TW |
dc.contributor.author | M-F Wu | zh-TW |
dc.contributor.author | C-Y Lin | zh-TW |
dc.contributor.author | 劉浩澧 | zh-TW |
dc.creator | H-L Liu;H-Y Hsieh;L-A Lu;C-W Kang;M-F Wu;C-Y Lin | - |
dc.date.accessioned | 2020-10-07T01:24:55Z | - |
dc.date.available | 2020-10-07T01:24:55Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 14795876 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/516662 | - |
dc.description.abstract | Background: High-intensity focused-ultrasound (HIFU) has been successfully employed for thermal ablation of tumors in clinical settings. Continuous- or pulsed-mode HIFU may also induce a host antitumor immune response, mainly through expansion of antigen-presenting cells in response to increased cellular debris and through increased macrophage activation/infiltration. Here we demonstrated that another form of focused ultrasound delivery, using low-pressure, pulsed-mode exposure in the presence of microbubbles (MBs), may also trigger an antitumor immunological response and inhibit tumor growth.Methods: A total of 280 tumor-bearing animals were subjected to sonographically-guided FUS. Implanted tumors were exposed to low-pressure FUS (0.6 to 1.4 MPa) with MBs to increase the permeability of tumor microvasculature.Results: Tumor progression was suppressed by both 0.6 and 1.4-MPa MB-enhanced FUS exposures. We observed a transient increase in infiltration of non-T regulatory (non-Treg) tumor infiltrating lymphocytes (TILs) and continual infiltration of CD8+ cytotoxic T-lymphocytes (CTL). The ratio of CD8+/Treg increased significantly and tumor growth was inhibited.Conclusions: Our findings suggest that low-pressure FUS exposure with MBs may constitute a useful tool for triggering an anticancer immune response, for potential cancer immunotherapy. ? 2012 Liu et al.; licensee BioMed Central Ltd. | - |
dc.relation.ispartof | Journal of Translational Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | animal cell; animal experiment; animal model; animal tissue; article; cancer inhibition; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; echography; high intensity focused ultrasound; low pressure pulsed focused ultrasound; lymphocytic infiltration; microbubble; microvasculature; mouse; nonhuman; permeability; regulatory T lymphocyte; tumor immunity; tumor microvasculature; Animals; Computer Systems; Disease Progression; Flow Cytometry; Humans; Immunity; Mice; Mice, Inbred BALB C; Microbubbles; Microscopy, Fluorescence; Microvessels; Models, Immunological; Neoplasms; Permeability; Pressure; Temperature; Tumor Microenvironment; Ultrasonics | - |
dc.title | Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/1479-5876-10-221 | - |
dc.identifier.scopus | 2-s2.0-84868536429 | - |
dc.relation.pages | 1-12 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 221 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
顯示於: | 電機工程學系 |
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