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  2. College of Medicine / 醫學院
  3. School of Dentistry / 牙醫專業學院
  4. Dentistry / 牙醫學系
  5. MMP-3 response to compressive forces in vitro and in vivo
 
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MMP-3 response to compressive forces in vitro and in vivo

Journal
Journal of Dental Research
Journal Volume
87
Journal Issue
7
Pages
692-696
Date Issued
2008
Author(s)
HAO-HUENG CHANG  
Wu C.-B.
ALEX YUNN-JY CHEN  
Weng C.-Y.
Wong W.-P.
Chang B.-E.
BEI-EN CHANG  
MIN-HUEY CHEN  
JANE CHUNG-CHEN YAO  
YI-JANE CHEN  
DOI
10.1177/154405910808700714
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-47649108546&doi=10.1177%2f154405910808700714&partnerID=40&md5=0c4c3c281c1fe632df630acc45b1c324
https://scholars.lib.ntu.edu.tw/handle/123456789/516811
Abstract
During orthodontic tooth movement, bone resorption occurs at the compression site. However, the mechanism underlying resorption remains unclear. Applying compressive force to human osteoblast-like cells grown in a 3D collagen gel, we examined gene induction by using microarray and RT-PCR analysis. Among 43 genes exhibiting significant changes, cyclooxygenase-2, ornithine decarboxylase, and matrix metalloproteinase-3 (MMP-3) were up-regulated, whereas membrane-bound interleukin-1 receptor accessory protein was down-regulated. The MMP-3 protein increases were further confirmed by Western blot. To ascertain whether MMP-3 is up-regulated in vivo by orthodontic force, we examined human bone samples at the compressive site by realigning the angulated molars. Immunohistochemical staining revealed MMP-3 distributed along the compressive site of the bony region within 3 days of compression. Since MMP-3 participates in degradation of a wide range of extracellular matrix molecules, we propose that MMP-3 plays an important role in bone resorption during orthodontic tooth movement.
SDGs

[SDGs]SDG3

Other Subjects
collagen; cyclooxygenase 2; ornithine decarboxylase; PTGS2 protein, human; stromelysin; adaptation; article; biological model; bone remodeling; cell culture; culture technique; cytology; DNA microarray; enzymology; gel; gene expression profiling; gene expression regulation; human; jaw; metabolism; nonparametric test; osteoblast; periodontal disease; physiology; Adaptation, Physiological; Alveolar Process; Bone Remodeling; Cell Culture Techniques; Cells, Cultured; Collagen; Cyclooxygenase 2; Gels; Gene Expression Profiling; Gene Expression Regulation; Humans; Matrix Metalloproteinase 3; Models, Biological; Oligonucleotide Array Sequence Analysis; Ornithine Decarboxylase; Osteoblasts; Statistics, Nonparametric; Tooth Movement
Type
journal article

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