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  4. Antihypertensive agents and the risk of breast cancer in women aged 55 years and older: A nested case-control study
 
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Antihypertensive agents and the risk of breast cancer in women aged 55 years and older: A nested case-control study

Journal
Journal of Hypertension
Journal Volume
34
Journal Issue
3
Pages
558-566
Date Issued
2016
Author(s)
CHIA-HSUIN CHANG  
CHIEN-HSIEH CHIANG  
CHUNG-JEN YEN  
Wu L.-C.
JOU-WEI LIN  
Lai M.-S.
DOI
10.1097/HJH.0000000000000813
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957570513&doi=10.1097%2fHJH.0000000000000813&partnerID=40&md5=43b3903a5d4622671c94cbf29c58b5d1
https://scholars.lib.ntu.edu.tw/handle/123456789/516887
Abstract
Objective: The study aimed to investigate the association of long-term use of different antihypertensive agents with incident breast cancer. Methods: A total of 794533 women aged at least 55 years were identified from Taiwan National Health Insurance claims database during 2001-2011. As of 31 December 2011, incident breast cancer patients were included as cases, and 1:4 age-matched controls were selected by risk-set sampling scheme. Logistic regression models were applied to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer incidence associated with different durations of use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β-blockers, and dihydropyridine calcium channel blockers (DHP CCBs). Different restriction rules were applied to reveal the potential effects of confounding by indication. Results: Among the 9397 incident breast cancer patients and 37588 controls, a significantly elevated risk was found for relatively short-term use of DHP CCBs (<6 years) but not in those observed for more than 6 years. There was no association between either angiotensin-converting enzyme inhibitors/angiotensin receptor blockers or β-blockers use and breast cancer. Although restricting our analyses to those with any prescription of antihypertensive medications in 2001 or those with diagnosis of hypertension, there was no longer a statistically significant association between any use of DHP CCBs and breast cancer (OR: 1.21, 95% CI: 0.88-1.67 for the former, and OR: 1.71, 95% CI: 0.99-2.95 for the latter). Conclusion: The results demonstrated the potential effect of confounding by indication, and thus, did not suggest any association of the use of antihypertensive medication and breast cancer risk. ? Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
angiotensin receptor antagonist; antihypertensive agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; dihydropyridine; dipeptidyl carboxypeptidase inhibitor; antihypertensive agent; dihydropyridine derivative; adult; Article; breast cancer; cancer incidence; cancer risk; case control study; controlled study; disease association; disease duration; drug effect; drug indication; drug use; female; high risk patient; hormone substitution; human; hypertension; long term care; major clinical study; middle aged; prescription; priority journal; risk assessment; risk factor; short course therapy; aged; Breast Neoplasms; hypertension; incidence; odds ratio; statistical model; Taiwan; Adrenergic beta-Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Breast Neoplasms; Calcium Channel Blockers; Case-Control Studies; Dihydropyridines; Female; Humans; Hypertension; Incidence; Logistic Models; Middle Aged; Odds Ratio; Risk Factors; Taiwan
Publisher
Lippincott Williams and Wilkins
Type
journal article

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