https://scholars.lib.ntu.edu.tw/handle/123456789/517339
標題: | Assessment of Barrett's esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography | 作者: | Ahsen O.O. Liang K. HSIANG-CHIEH LEE Giacomel Li M.G. Wang Z. Potsaid B. Figueiredo M. Huang Q. Jayaraman V. Fujimoto J.G. Mashimo H. Ahsen O.O. Liang K. Giacomel Li M.G. Wang Z. Potsaid B. Figueiredo M. Huang Q. Jayaraman V. Fujimoto J.G. Mashimo H. |
公開日期: | 2019 | 卷: | 51 | 期: | 4 | 起(迄)頁: | 355-359 | 來源出版物: | Endoscopy | 摘要: | Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett's esophagus and dysplasia. Methods ?74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett's esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett's esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signaľ>subsurface, anď>5 atypical glands on cross-sectional OCT vs. histology and treatment history were assessed by three blinded readers. Results ?Atypical glands under irregular mucosal patterns occurred in 75% of neoplasia (96% of treatment-naïve neoplasia) vs. 30% of NDBE datasets (43% of short- and 18% of long-segment NDBE). Mucosal layering was absent in 35% of neoplasia and 50% of NDBE datasets, and surface signaľ>subsurface occurred in 29% of neoplasia and 30% of NDBE datasets. Conclusions ?Atypical glands under irregular mucosal patterns are strongly associated with neoplasia, suggesting potential markers for dysplasia and a role in pathogenesis. © 2019 Georg Thieme Verlag KG Stuttgart New York. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063238247&doi=10.1055%2fa-0725-7995&partnerID=40&md5=f95064ccb2c37cee7f22cd65fb6aaab7 https://scholars.lib.ntu.edu.tw/handle/123456789/517339 |
DOI: | 10.1055/a-0725-7995 | SDG/關鍵字: | Article; Barrett esophagus; clinical assessment; controlled study; correlation analysis; disease association; endoscopic mucosal resection; esophageal adenocarcinoma; esophagus biopsy; esophagus dysplasia; esophagus mucosa; gastroesophageal junction; histopathology; human; major clinical study; optical coherence tomography; pathogenesis; priority journal; white light endoscopy; Barrett esophagus; biopsy; diagnostic imaging; esophagoscopy; esophagus mucosa; esophagus tumor; female; male; middle aged; optical coherence tomography; pathology; precancer; procedures; reproducibility; Barrett Esophagus; Biopsy; Esophageal Mucosa; Esophageal Neoplasms; Esophagoscopy; Female; Humans; Male; Middle Aged; Precancerous Conditions; Reproducibility of Results; Tomography, Optical Coherence |
顯示於: | 電機工程學系 |
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