Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
Journal
Journal of Biomedical Optics
Journal Volume
22
Journal Issue
7
Date Issued
2017
Author(s)
Ahsen O.O.
Liu J.J.
Tsai T.-H.
Huang Q.
Mashimo H.
Fujimoto J.G.
Ahsen O.O.
Liu J.J.
Tsai T.-H.
Huang Q.
Mashimo H.
Fujimoto J.G.
Abstract
Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett's esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum formation using RFA applications with different energy settings, and (2) M-mode OCT imaging for monitoring the dynamics of tissue architectural changes in real time during RFA application. Post-RFA volumetric OCT measurements showed an increase in the coagulum thickness with respect to the increasing RFA energies. Using a subset of the specimens, OCT measurements of coagulum and coagulum + residual EP thickness were shown to agree with histology, which accounted for specimen shrinkage during histological processing. In addition, we demonstrated the feasibility of OCT for real-time visualization of the architectural changes during RFA application with different energy settings. Results suggest feasibility of using OCT for RFA treatment planning and guidance. © 2017 The Authors.
Subjects
ablation of tissue; endoscopic imaging; gastrointestinal; medical and biological imaging; optical coherence tomography
Other Subjects
Ablation; Architecture; Coherent light; Medical imaging; Patient treatment; Tissue; Tomography; Application protocols; Architectural changes; Endoscopic imaging; gastrointestinal; High-speed optical coherence tomography; Medical and biological imaging; Radiofrequency ablation; Real time visualization; Optical tomography; animal experiment; animal model; animal tissue; endoscopy; epithelium; esophagus tissue; feasibility study; gastrointestinal tract; histology; model; monitoring; nonhuman; optical coherence tomography; pig; quantitative analysis; radiofrequency ablation; thickness; treatment planning; velocity; catheter ablation; devices; esophagoscopy; esophagus tumor; human; treatment outcome; Catheter Ablation; Esophageal Neoplasms; Esophagoscopy; Humans; Tomography, Optical Coherence; Treatment Outcome
Type
journal article