Herpes zoster-associated severity and duration of pain, health-related quality of life, and healthcare utilization in TWN: A prospective observational study
Journal
International Journal of Dermatology
Journal Volume
54
Journal Issue
5
Pages
529-536
Date Issued
2015
Author(s)
Yu H.-S.
Lan C.-C.
Chao S.-C.
Yang J.-H.
Yang K.-C.
Chen C.-Y.
White R.R.
Psaradellis E.
Rampakakis E.
Kawai K.
Acosta C.J.
Sampalis J.S.
Abstract
Background: To assess the severity and duration of herpes zoster (HZ)-associated pain (ZAP) and its impact on quality of life (QoL) and healthcare utilization (HCRU) from a patient perspective in routine care in TWN. Methods: A prospective, observational, single-cohort study was conducted in five centers across TWN. Patients were recruited at different time points during their HZ episode and were followed for ?180?days. ZAP was assessed with the Initial Zoster Impact Questionnaire and the Zoster Brief Pain Inventory, QoL with the EQ-5D, and HCRU with a simple questionnaire. Results: A total of 150 patients were included with a mean age of 64.9?years and mean time since rash onset of 18.8?days. Prodromal pain was experienced by 64.7% of patients, of whom 91.8% reported moderate-to-severe pain. At enrollment, 98.0% of patients experienced ZAP. Mean?±?SD worst pain score decreased from 5.95?±?3.09 at enrollment to 2.65?±?2.98 at 30?days and 0.28?±?0.83 at 180?days. Postherpetic neuralgia was observed in 20.7% of patients. Mean?±?SD EQ-5D score significantly decreased (P?
SDGs
Other Subjects
aciclovir; famciclovir; topical agent; valaciclovir; adult; aged; antiviral therapy; Article; cohort analysis; daily life activity; dermatome; deterioration; disease duration; disease severity; emergency ward; female; follow up; health care utilization; health status; herpes zoster; hospitalization; human; Initial Zoster Impact Questionnaire; major clinical study; male; medical specialist; observational study; pain severity; physician; physiotherapist; postherpetic neuralgia; prospective study; quality of life; rash; Taiwan; Zoster Brief Pain Inventory; complication; herpes zoster; Neuralgia, Postherpetic; patient attitude; quality of life; questionnaire; severity of illness index; statistics and numerical data; time; Female; Herpes Zoster; Humans; Male; Neuralgia, Postherpetic; Patient Acceptance of Health Care; Prospective Studies; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Taiwan; Time Factors
Publisher
Blackwell Publishing Ltd
Type
journal article