https://scholars.lib.ntu.edu.tw/handle/123456789/517613
Title: | Herpes zoster-associated severity and duration of pain, health-related quality of life, and healthcare utilization in TWN: A prospective observational study | Authors: | TSEN-FANG TSAI CHIEN-AN YAO Yu H.-S. Lan C.-C. Chao S.-C. Yang J.-H. Yang K.-C. Chen C.-Y. White R.R. Psaradellis E. Rampakakis E. Kawai K. Acosta C.J. Sampalis J.S. |
Issue Date: | 2015 | Publisher: | Blackwell Publishing Ltd | Journal Volume: | 54 | Journal Issue: | 5 | Start page/Pages: | 529-536 | Source: | International Journal of Dermatology | Abstract: | Background: To assess the severity and duration of herpes zoster (HZ)-associated pain (ZAP) and its impact on quality of life (QoL) and healthcare utilization (HCRU) from a patient perspective in routine care in TWN. Methods: A prospective, observational, single-cohort study was conducted in five centers across TWN. Patients were recruited at different time points during their HZ episode and were followed for ?180?days. ZAP was assessed with the Initial Zoster Impact Questionnaire and the Zoster Brief Pain Inventory, QoL with the EQ-5D, and HCRU with a simple questionnaire. Results: A total of 150 patients were included with a mean age of 64.9?years and mean time since rash onset of 18.8?days. Prodromal pain was experienced by 64.7% of patients, of whom 91.8% reported moderate-to-severe pain. At enrollment, 98.0% of patients experienced ZAP. Mean?±?SD worst pain score decreased from 5.95?±?3.09 at enrollment to 2.65?±?2.98 at 30?days and 0.28?±?0.83 at 180?days. Postherpetic neuralgia was observed in 20.7% of patients. Mean?±?SD EQ-5D score significantly decreased (P?0.001) from 0.91?±?0.16 before rash onset to 0.67?±?0.18 after rash onset, showing significant QoL deterioration up to 60?days. The impact of HZ on QoL and pain severity was similar across age groups. Significant HCRU was observed including visits to the doctor (83.3% of patients), specialist (30.7%), emergency department (24.7%), physiotherapist (23.3%), and hospitalizations (20.7%). Conclusion: Severe morbidity and significant HCRU are associated with HZ in TWN, supporting the need for early intervention and preventive strategies to reduce the HZ-associated burden of illness. ? 2014 The International Society of Dermatology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928325439&doi=10.1111%2fijd.12484&partnerID=40&md5=b1f0796838390f6340873963e1eace25 https://scholars.lib.ntu.edu.tw/handle/123456789/517613 |
ISSN: | 0011-9059 | DOI: | 10.1111/ijd.12484 | SDG/Keyword: | aciclovir; famciclovir; topical agent; valaciclovir; adult; aged; antiviral therapy; Article; cohort analysis; daily life activity; dermatome; deterioration; disease duration; disease severity; emergency ward; female; follow up; health care utilization; health status; herpes zoster; hospitalization; human; Initial Zoster Impact Questionnaire; major clinical study; male; medical specialist; observational study; pain severity; physician; physiotherapist; postherpetic neuralgia; prospective study; quality of life; rash; Taiwan; Zoster Brief Pain Inventory; complication; herpes zoster; Neuralgia, Postherpetic; patient attitude; quality of life; questionnaire; severity of illness index; statistics and numerical data; time; Female; Herpes Zoster; Humans; Male; Neuralgia, Postherpetic; Patient Acceptance of Health Care; Prospective Studies; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Taiwan; Time Factors |
Appears in Collections: | 醫學系 |
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