https://scholars.lib.ntu.edu.tw/handle/123456789/517902
標題: | Plasma leptin levels and digital pulse volume in obese patients without metabolic syndrome - A pilot study | 作者: | YEN-HUNG LIN YI-LWUN HO JEN-KUANG LEE HSIEN-LIANG HUANG KUO-CHIN HUANG MING-FONG CHEN |
公開日期: | 2011 | 卷: | 412 | 期: | 44084 | 起(迄)頁: | 730-734 | 來源出版物: | Clinica Chimica Acta | 摘要: | Background: The mechanism of obesity leading to endothelial function is complex, and involves many adipokines and inflammatory cytokines. The data is especially lacking in obese patients without metabolic syndrome. We assessed the relationship among endothelial dysfunction, anthropometric indices, adipokines and inflammatory cytokines in this population. Methods: Obese patients without metabolic syndrome were included in this study. The plasma resistin, leptin, retinol-binding-protein 4 and inflammatory cytokines were examined. Endothelial function was assessed by a fingertip peripheral arterial tonometry (PAT) device. Data are expressed as the natural logarithm (ln) of the PAT ratio. Endothelial dysfunction was defined by a ln (PAT ratio) < 0.30. Results: A total of 35 patients were enrolled, 11 of whom were with endothelial dysfunction. There was a significant difference of ln leptin (p = 0.007), ln [leptin/visceral fat thickness] (p = 0.004) and ln [leptin/subcutaneous fat thickness] (p < 0.001) between patients with and without endothelial dysfunction. Multivariate linear regression analyses showed that ln [leptin/subcutaneous fat thickness] was significantly related to the ln (PAT ratio) (p = 0.002). Using ln [leptin/subcutaneous fat thickness] to detect endothelial dysfunction, the area of receiver operating characteristic curves was 0.843 (p = 0.002). Using 6.10 as a cutoff point, the sensitivity and specificity to determine endothelial dysfunction were 91% and 78%, respectively. Conclusion: Abnormal digital vascular function occurs in obese patients without metabolic syndrome. Low plasma leptin/subcutaneous fat ratio is associated with endothelial dysfunction in this population. ? 2011 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951726914&doi=10.1016%2fj.cca.2010.12.032&partnerID=40&md5=edf3d665c9c942d580ab9535bc881b31 https://scholars.lib.ntu.edu.tw/handle/123456789/517902 |
ISSN: | 0009-8981 | DOI: | 10.1016/j.cca.2010.12.032 | SDG/關鍵字: | cytokine; leptin; resistin; retinol binding protein 4; adult; article; cardiovascular parameters; clinical article; digital pulse volume; disease association; endothelial dysfunction; female; human; intraabdominal fat; male; metabolic syndrome X; obesity; pilot study; priority journal; protein blood level; subcutaneous fat; tonometry; Adipose Tissue; Adult; Age Factors; Arteries; Body Mass Index; Cytokines; Endothelium, Vascular; Female; Humans; Inflammation; Leptin; Male; Manometry; Metabolic Syndrome X; Obesity; Pilot Projects; Sex Factors |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。