|Title:||Symptom patterns and subgrouping of schizophrenic patients: Significance of negative symptoms assessed on admission||Authors:||Hwu H.-G.
|Keywords:||Follow-up; Generalized association plots; Schizophrenia subtypes; Symptom dimensions; Validity||Issue Date:||2002||Journal Volume:||56||Journal Issue:||1-2||Start page/Pages:||105-119||Source:||Schizophrenia Research||Abstract:||
This study subgroups schizophrenic patients based on symptoms assessed on admission and examines the validity of the subgrouping using follow-up data and other clinical outcome variables. Schizophrenic patients (n=163) from consecutive admission received ratings on the positive and negative syndrome scale (PANSS) on admission and during a 1-year follow-up course. An exploratory graphic analysis on the admission PANSS derived four symptom dimensions: negative symptoms, disorganized thought, hostility/excitement and delusions/hallucinations. This yielded two subgroups of patients on admission, a group with marked negative (GWNEG) and a group without marked negative (GONEG) symptoms. Compared with the GONEG, the GWNEG had a poorer recovery rate, more impairment in attention, a slower response of the delusion/hallucination symptoms to neuroleptic treatment and a longer duration of index hospitalization. At a one-year follow-up, the GWNEG assessed on admission had persistently higher scores on the negative symptom and disorganized thought syndromes, less relapse rate, a shorter duration on job, as well as worse social functioning than the GONEG. Thus, the GONEG might comprise patients having a pure paranoid syndrome with quick and better treatment response, while the GWNEG comprises patients with the blunt-disorganization syndrome having a poorer outcome. ? 2002 Elsevier Science B.V. All rights reserved.
|ISSN:||0920-9964||DOI:||10.1016/S0920-9964(01)00251-1||metadata.dc.subject.other:||chlorpromazine; trihexyphenidyl; adult; article; clinical feature; controlled study; delusion; disease severity; disorientation; female; follow up; hallucination; hospital admission; hostility; human; job performance; length of stay; major clinical study; male; negative syndrome; outcomes research; priority journal; rating scale; relapse; schizophrenia; social status; symptom; validation process; Adult; Depression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Admission; Prospective Studies; Psychiatric Status Rating Scales; Psychometrics; Schizophrenia; Schizophrenic Psychology
|Appears in Collections:||醫療器材與醫學影像研究所|
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