https://scholars.lib.ntu.edu.tw/handle/123456789/518199
標題: | Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas | 作者: | Liao C.-T Wen Y.-W Yang L.Y Lee S.R Ng S.-H Liu T.-W Tsai S.-T Tsai M.-H Lin J.-C Chen P.-R PEI-JEN LOU CHENG-PING WANG Chu P.-Y Hwang T.-Z Leu Y.-S Tsai K.-Y Terng S.-D Chen T.-M Wang C.-H Chien C.-Y Chen W.-C Lee L.-Y Lin C.-Y Wang H.-M Hsieh C.-H Tsao C.-K Fang T.-J Huang S.-F Kang C.-J Chang K.-P Yen T.-C. |
公開日期: | 2017 | 出版社: | Elsevier Ltd | 卷: | 67 | 起(迄)頁: | 95-102 | 來源出版物: | Oral Oncology | 摘要: | Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, p = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (?65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former. ? 2017 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013141413&doi=10.1016%2fj.oraloncology.2017.02.011&partnerID=40&md5=c1c4875b741949d2dc8c94199ba40c8d https://scholars.lib.ntu.edu.tw/handle/123456789/518199 |
ISSN: | 1368-8375 | DOI: | 10.1016/j.oraloncology.2017.02.011 | SDG/關鍵字: | adult; aged; Article; buccal squamous cell carcinoma; cancer adjuvant therapy; cancer patient; cancer prognosis; cancer radiotherapy; cancer registry; cancer staging; cancer surgery; cancer survival; clinical outcome; cohort analysis; disease specific survival; female; health promotion; human; major clinical study; male; mouth carcinoma; mouth cavity; multimodality cancer therapy; outcome assessment; overall survival; prevalence; priority journal; squamous cell carcinoma; Taiwan; Taiwanese; tongue carcinoma; cheek; comparative study; middle aged; pathology; retrospective study; squamous cell carcinoma; tongue tumor; treatment outcome; Adult; Aged; Carcinoma, Squamous Cell; Cheek; Female; Humans; Male; Middle Aged; Retrospective Studies; Taiwan; Tongue Neoplasms; Treatment Outcome |
顯示於: | 醫學系 |
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