https://scholars.lib.ntu.edu.tw/handle/123456789/518237
標題: | Use of transnasal endoscopy for screening of esophageal squamous cell carcinoma in high-risk patients: Yield rate, completion rate, and safety | 作者: | Wang C.-H. YI-CHIA LEE CHENG-PING WANG CHIEN-CHUAN CHEN JENG-YUH KO MING-LUN HAN TSENG-CHENG CHEN PEI-JEN LOU TSUNG-LIN YANG Hsiao T.-Y. MING-SHIANG WU HSIU-PO WANG PING-HUEI TSENG |
公開日期: | 2014 | 卷: | 26 | 期: | 1 | 起(迄)頁: | 24-31 | 來源出版物: | Digestive Endoscopy | 摘要: | Background Patients with head and neck squamous cell carcinoma are at high risk for synchronous and/or metachronous esophageal cancer. The present study aimed to evaluate the feasibility and safety of unsedated transnasal endoscopy (TNE) for screening these high-risk patients. Patients and Methods Consecutive high-risk patients including patients with suspicious or diagnosed head and neck cancer or patients with alarming symptoms received screening TNE. All endoscopic procedures, including sequential conventional white-light, narrow-band imaging, and Lugol chromoendoscopy, were done without sedation. All suspicious lesions in the esophagus were biopsied for histological evaluation. The completion rate, procedure time, and significant adverse events of all endoscopic procedures were recorded and analyzed. Results From May 2007 to August 2011, a total of 500 TNE were carried out in 441 high-risk patients. Among them, 294 patients (66.7%) had diagnosed head and neck squamous cellcarcinoma, and most were hypopharyngeal cancer (n = 186). Esophageal squamous cell carcinomas and high-grade intraepithelial neoplasms were detected in 10.1% and 7.3%, respectively, of the cases. Completion rate of TNE in head and neck cancer was 96.7%; tumor obstruction and stenosis of anastomosis site were the main reasons for incomplete procedures. Mean duration of the endoscopic procedure was 14.6 min. One patient had post-endoscopic epistaxis while another patient had post-biopsy hemoptysis, both of whom were treated conservatively. No procedure-related mortality or significant morbidity occurred. Conclusion Unsedated TNE is safe and feasible for screening synchronous or metachronous esophageal neoplasms in high-risk patients, especially those with head and neck cancer. ? 2013 The Authors. Digestive Endoscopy ? 2013 Japan Gastroenterological Endoscopy Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891629584&doi=10.1111%2fden.12053&partnerID=40&md5=cb6637fa3264ea1578856ff3c3e38931 https://scholars.lib.ntu.edu.tw/handle/123456789/518237 |
ISSN: | 0915-5635 | DOI: | 10.1111/den.12053 | SDG/關鍵字: | lugol; adolescent; adult; advanced cancer; adverse outcome; aged; anastomosis; article; cancer diagnosis; cancer screening; chromoendoscopy; conservative treatment; diagnostic value; endoscope; endoscopy; epistaxis; esophageal intraepithelial neoplasm; esophageal squamous cell carcinoma; esophagus biopsy; esophagus cancer; female; head and neck cancer; head and neck squamous cell carcinoma; hemoptysis; high risk patient; histology; human; hypopharynx cancer; major clinical study; male; narrow band imaging; oncological parameters; patient safety; stenosis; stomach adenocarcinoma; transnasal endoscopy; tumor obstruction; very elderly; esophageal screening; esophageal squamous cell carcinoma (ESCC); head and neck cancer; hypopharyngeal cancer; squamous cell carcinoma; transnasal endoscopy (TNE); Adult; Aged; Carcinoma, Squamous Cell; Chemoradiotherapy; Conscious Sedation; Endoscopy; Esophageal Neoplasms; Feasibility Studies; Female; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Image Enhancement; Male; Middle Aged |
顯示於: | 醫學系 |
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