The synthesis and photodynamic properties of meso-substituted, cationic porphyrin derivatives in HeLa cells
Journal
Dyes and Pigments
Journal Volume
84
Journal Issue
1
Pages
140-147
Date Issued
2010
Author(s)
Abstract
A series of asymmetric porphyrins with varying substituents, such as 4-hydrophenyl and N-methyl-4-pyridyl, were synthesized and characterized and their cell uptake, intracellular localization, cytotoxicities and phototoxicities were evaluated in vitro. The most phototoxic of the porphyrins synthesized, 5,10-di-(N-methyl-4-pyridyl)-15,20-(4-hydroxyphenyl)-21,23H-porphyrin, which was mainly localized in the mitochondria and displayed low levels of dark toxicity toward human cancer HeLa cells, offers potential application in photodynamic therapy. ? 2009 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
Asymmetric porphyrins; Cancer; Cationic porphyrin; Cell uptake; HeLa cell; Human cancer; In-vitro; Intracellular localization; Low level; Partition coefficients; Potential applications; Pyridyl; Synthesis; Cell membranes; Derivatives; Mitochondria; Optical materials; Plasmons; Porphyrins; Synthesis (chemical); Photodynamic therapy; chemical analysis; chemical compound; chemical reaction; disease; synthesis; toxicity
Type
journal article