https://scholars.lib.ntu.edu.tw/handle/123456789/518289
標題: | Improved diagnostic accuracy of malignant neck lumps by a simple BMVC staining assay | 作者: | Liao L.-J. Kang C.-C. I-SHIOW JAN Chen H.-C. Wang C.-L. PEI-JEN LOU Chang T.-C. |
公開日期: | 2009 | 出版社: | Royal Society of Chemistry | 卷: | 134 | 期: | 4 | 起(迄)頁: | 708-711 | 來源出版物: | Analyst | 摘要: | A handheld device based on fluorescence of 3,6-bis(1-methyl-4- vinylpyridinium)carbazole diiodide (BMVC) staining was established for the rapid, point-of-care screening of cancer cells (see Chang and co-workers, Analyst, 2007, 132, 745). Offering instant screening of cancer at low cost, here we apply this simple assay in clinical tests on fine needle aspirates of neck masses from 114 outpatients (115 specimens). The diagnostic accuracy of this simple method alone is ca. 80% (80/99). The combination of the BMVC test and the fine needle aspiration (FNA) cytology reduced the non-diagnosis from 17 cases in FNA cytology to 6 cases in the combined method. Moreover, an algorithm is proposed to improve the diagnostic accuracy of malignant neck lumps up to nearly 100%. ? 2009 The Royal Society of Chemistry. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67149096172&doi=10.1039%2fb814417f&partnerID=40&md5=87f6d14b51797c0480556d374a838f1e https://scholars.lib.ntu.edu.tw/handle/123456789/518289 |
ISSN: | 0003-2654 | DOI: | 10.1039/b814417f | SDG/關鍵字: | 3,6 bis(1 methyl 4 vinylpyridinium)carbazole diiodide; iodine derivative; unclassified drug; adolescent; adult; aged; algorithm; article; aspiration biopsy; cancer diagnosis; child; controlled study; cytology; diagnostic accuracy; diagnostic value; female; human; human cell; intermethod comparison; major clinical study; male; malignant neoplastic disease; neck tumor; outpatient; school child; sensitivity and specificity; staining |
顯示於: | 醫學系 |
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