Improved diagnostic accuracy of malignant neck lumps by a simple BMVC staining assay
Journal
Analyst
Journal Volume
134
Journal Issue
4
Pages
708-711
Date Issued
2009
Author(s)
Abstract
A handheld device based on fluorescence of 3,6-bis(1-methyl-4- vinylpyridinium)carbazole diiodide (BMVC) staining was established for the rapid, point-of-care screening of cancer cells (see Chang and co-workers, Analyst, 2007, 132, 745). Offering instant screening of cancer at low cost, here we apply this simple assay in clinical tests on fine needle aspirates of neck masses from 114 outpatients (115 specimens). The diagnostic accuracy of this simple method alone is ca. 80% (80/99). The combination of the BMVC test and the fine needle aspiration (FNA) cytology reduced the non-diagnosis from 17 cases in FNA cytology to 6 cases in the combined method. Moreover, an algorithm is proposed to improve the diagnostic accuracy of malignant neck lumps up to nearly 100%. ? 2009 The Royal Society of Chemistry.
SDGs
Other Subjects
3,6 bis(1 methyl 4 vinylpyridinium)carbazole diiodide; iodine derivative; unclassified drug; adolescent; adult; aged; algorithm; article; aspiration biopsy; cancer diagnosis; child; controlled study; cytology; diagnostic accuracy; diagnostic value; female; human; human cell; intermethod comparison; major clinical study; male; malignant neoplastic disease; neck tumor; outpatient; school child; sensitivity and specificity; staining
Publisher
Royal Society of Chemistry
Type
journal article