https://scholars.lib.ntu.edu.tw/handle/123456789/518335
標題: | Delayed irradiation effects on nasal epithelium in patients with nasopharyngeal carcinoma. An ultrastructural study | 作者: | WEN-PIN CHEN PEI-JEN LOU Tai C.C. |
公開日期: | 1999 | 出版社: | Annals Publishing Company | 卷: | 108 | 期: | 5 | 起(迄)頁: | 474-480 | 來源出版物: | Annals of Otology, Rhinology and Laryngology | 摘要: | The ostiomeatal complex is responsible for the clearance of most sinus secretions. To evaluate the delayed effects of irradiation, this study examined the infundibulum mucosa of 10 patients who developed sinusitis after receiving radiotherapy for nasopharyngeal carcinoma (NPC). Pathologic findings under the light microscope revealed an increased deposition of dense collagenous fibers in the lamina propria. The epithelial cells also transformed into a stratified arrangement and showed gradual reduction of cytoplasmic volume. Ultrastructural observations detected areas of ciliary loss, intercellular and intracellular vacuolation, and ciliary dysmorphism. Most of these pathologic findings were observed even in a patient 23 years after irradiation. The results presented herein suggest that radiotherapy may cause long-term damage to the nasal epithelium that may be responsible for the prolonged sinusitis of irradiated NPC patients. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345104425&doi=10.1177%2f000348949910800510&partnerID=40&md5=a4384ddc97e33a02ca3fd998a255b3d5 https://scholars.lib.ntu.edu.tw/handle/123456789/518335 |
ISSN: | 0003-4894 | DOI: | 10.1177/000348949910800510 | SDG/關鍵字: | adult; aged; article; cancer radiotherapy; cell transformation; cell ultrastructure; clinical article; controlled study; female; human; human tissue; irradiation; male; nasopharynx carcinoma; nose mucosa; priority journal; radiation sickness; sinusitis |
顯示於: | 醫學系 |
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