https://scholars.lib.ntu.edu.tw/handle/123456789/518344
標題: | Increased mutagen sensitivity in patients with head and neck cancer is less pronounced in patients with nasopharyngeal carcinoma | 作者: | JENG-YUH KO Lui L.T Sheen T.-S PEI-JEN LOU Hsu M.-M. |
公開日期: | 1998 | 出版社: | American Medical Association | 卷: | 124 | 期: | 5 | 起(迄)頁: | 578-581 | 來源出版物: | Archives of Otolaryngology - Head and Neck Surgery | 摘要: | Background: Mutagen sensitivity tested with bleomycin sulfate can determine a susceptible phenotype, which is relevant only in organs and tissues that have direct contact with the external environment. Patients with head and neck cancers have more mutagen sensitivity than control subjects without cancer, and the hypersensitive phenotype has a risk for the development of a second primary cancer. Head and neck cancers, however, represent a heterogeneous group of neoplasm. The biological behavior of nasopharyngeal carcinoma (NPC) and other head and neck cancers differs. Objective: To evaluate the difference in mutagen sensitivity among patients without cancer, patients with NPC, patients with oral or oropharyngeal cancer (ORC), and patients with laryngeal or hypopharyngeal cancer (LHC). Design: Peripheral blood was cultured at 37°C, using 5% carbon dioxide, for 72 hours. After 67 hours of incubation, bleomycin in a concentration of 30 IU/L was added to induce chromatid breaks. The number of chromatid breaks per cell was scored in 50 metaphases of cultured lymphocytes and compared in the 4 groups. Subjects: Patients with histologically proven squamous cell carcinoma of the mucosa of the upper digestive tract, which included 3 groups: patients with NPC, patients with ORC, and those with LHC. Control subjects were hospital inpatients with no tumor history. There were 35 patients in each group. Results: The mean (±SD) number of breaks per cell in the control group and in the groups with NPC, ORC, and LHC were 0.80 (±0.32), 1.03 (±0.45), 1.30 (±0.44), and 1.35 (±0.46), respectively. All the cancer groups had significantly higher mean breaks per cell and a higher prevalence of hypersensitivity than the control group. Patients with NPC had a significantly lower mean number of breaks per cell than the group with ORC or that with LHC. Conclusions: Patients with NPC had less mutagen sensitivity than those with ORC or LHC. Our results support the clinical and epidemiological findings of a difference between NPC and other head and neck cancers. Environmental factors might play a less pronounced role in the carcinogenesis of NPC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031900064&doi=10.1001%2farchotol.124.5.578&partnerID=40&md5=cc4a01f31e1ee24419ead5464146b230 https://scholars.lib.ntu.edu.tw/handle/123456789/518344 |
ISSN: | 0886-4470 | DOI: | 10.1001/archotol.124.5.578 | SDG/關鍵字: | bleomycin sulfate; DNA; mutagenic agent; adult; aged; article; chemosensitivity; chromatid; chromosome breakage; controlled study; head and neck cancer; human; human cell; human tissue; hypopharynx cancer; larynx cancer; major clinical study; metaphase; mouth cancer; nasopharynx cancer; oropharynx cancer; squamous cell carcinoma |
顯示於: | 醫學系 |
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