https://scholars.lib.ntu.edu.tw/handle/123456789/519114
標題: | Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese | 作者: | TZY-HAW WU Fann J.C.-Y. Chen S.L.-S. Yen A.M.-F. Chiung-Jung Wen Lu Y.-R. Chen, Tony Hsiu Hsi Chiu S.Y.-H. HORNG-HUEI LIOU |
公開日期: | 2018 | 出版社: | Nature Publishing Group | 卷: | 8 | 期: | 1 | 起(迄)頁: | 16517 | 來源出版物: | Scientific Reports | 摘要: | The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease (CAD) in a large population- and community-based Taiwanese cohort. A longitudinal study with a 9-year follow-up was conducted to evaluate individuals aged 20 years or older who had participated in the Keelung (the northernmost city in Taiwan) community-based integrated screening (abbreviated as KCIS) program since September 1999. The mortality rates associated with CVD and CAD were classified across a range of different MCV levels. Increased MCV levels were associated with an increased risk of CVD/CAD-related death (adjusted hazard ratio [aHR] = 1.42, trend test P = 0.0119). Marginally statistically significant associations were noted for specific deaths from ischemic heart disease (aHR = 1.44, trend test P = 0.0992) and cerebral ischemic stroke (aHR = 1.66, trend test P = 0.0667), respectively, but no significant gradient relationship was noted for death from cerebral hemorrhage stroke (aHR = 1.23, trend test, P = 0.6278). A gradient relationship between baseline MCV level and CVD/CAD-related death was noted, but whether such gradient relationships existed for two specific deaths and how these relationships may be confounded by extraneous factors that were not considered here should be investigated in the future. ? 2018, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056256379&doi=10.1038%2fs41598-018-34403-w&partnerID=40&md5=fbccb5faa8d7864f0cc6ad406c42e90b https://scholars.lib.ntu.edu.tw/handle/123456789/519114 |
DOI: | 10.1038/s41598-018-34403-w | SDG/關鍵字: | adult; age distribution; aged; blood; brain ischemia; cardiovascular disease; cerebrovascular disease; complication; female; heart muscle ischemia; human; longitudinal study; male; mean corpuscular volume; middle aged; mortality; proportional hazards model; risk assessment; Taiwan; Adult; Age Distribution; Aged; Brain Ischemia; Cardiovascular Diseases; Cerebrovascular Disorders; Erythrocyte Indices; Female; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Ischemia; Proportional Hazards Models; Risk Assessment; Taiwan |
顯示於: | 醫學系 |
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