https://scholars.lib.ntu.edu.tw/handle/123456789/519167
標題: | Clinical efficacy and cognitive and neuropsychological effects of levetiracetam in epilepsy: An open-label multicenter study | 作者: | Wu T. Chen C.-C. Chen T.-C. Tseng Y.-F. Chiang C.-B. Hung C.-C. HORNG-HUEI LIOU |
公開日期: | 2009 | 卷: | 16 | 期: | 3 | 起(迄)頁: | 468-474 | 來源出版物: | Epilepsy and Behavior | 摘要: | The aim of this prospective, multicenter, open-label study was to investigate the efficacy of levetiracetam (LEV) and determine its effects on cognitive and neuropsychological function. Sixty-nine patients were evaluated for effects of LEV on seizure control, cognitive (Mini-Mental State Examination [MMSE]) and neuropsychological (Symptom Checklist-90 Revised [SCL-90-R]) functions, and quality of life (Quality of Life in Epilepsy-10 [QOLIE-10]) assessments at 3 and 12 months of follow-up. Thirty-nine percent of patients achieved seizure freedom, and 68% had a ?50% seizure frequency reduction after 1 year of LEV (1235.5 ± 392.7 mg/day). There were also significant improvements in mean MMSE score and in the recall and language items of MMSE. There were modest improvements in interpersonal sensitivity and paranoid ideation scales of the SCL-90-R, and improvements in cognition and medication effect items of the QOLIE-10. The results demonstrate that LEV not only effectively reduces seizure frequency, but also possibly contributes to improvements in neuropsychological functions such as recall, language, interpersonal sensitivity, and paranoid ideation. ? 2009. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70350620152&doi=10.1016%2fj.yebeh.2009.08.026&partnerID=40&md5=50f5e88b6c749cf483f87b35bcff51d7 https://scholars.lib.ntu.edu.tw/handle/123456789/519167 |
DOI: | 10.1016/j.yebeh.2009.08.026 | SDG/關鍵字: | carbamazepine; clonazepam; etiracetam; gabapentin; lamotrigine; oxcarbazepine; phenobarbital; phenytoin; tiagabine; topiramate; valproic acid; vigabatrin; adult; article; bradykinesia; clinical practice; clinical trial; cognition; controlled clinical trial; controlled study; diarrhea; disability; disease control; dizziness; dose response; drug dose titration; drug effect; drug efficacy; drug fatality; drug safety; drug tolerability; drug withdrawal; epilepsy; female; follow up; headache; hospitalization; human; language processing; major clinical study; male; mini mental state examination; monotherapy; multicenter study; neuropsychology; open study; paranoia; patient assessment; quality of life; Quality of Life in Epilepsy 10; quality of life index; rash; recall; side effect; social adaptation; somnolence; Symptom Checklist 90; treatment response; Adult; Analysis of Variance; Anticonvulsants; Cognition Disorders; Epilepsy; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Perception; Piracetam; Prospective Studies; Quality of Life; Retrospective Studies; Taiwan; Time Factors |
顯示於: | 醫學系 |
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