https://scholars.lib.ntu.edu.tw/handle/123456789/519474
標題: | Clinical dementia rating scale detects white matter changes in older adults at risk for Alzheimer's disease | 作者: | Chang, Y.-L. Yen, Y.-S. TA-FU CHEN Yan, S.-H. Chang, Yu-Ling |
公開日期: | 2016 | 出版社: | IOS Press | 卷: | 50 | 期: | 2 | 起(迄)頁: | 411-423 | 來源出版物: | Journal of Alzheimer's Disease | 摘要: | This study investigated the putative changes in regional gray matter and cingulum bundle segments in mild cognitive impairment (MCI) by using two diagnostic criteria. Participants comprised 50 older adults with MCI and 22 healthy older controls (HC). The older adults with MCI were further divided into two groups defined by a global Clinical Dementia Rating (CDR) score of 0.5 and with (the CDR/NPT MCI group) or without (the CDR MCI group) objective cognitive impairments determined using neuropsychological tests (NPTs). Comparable regional gray matter integrity was observed among the three groups. However, the integrity of the right inferior segment of the cingulum bundle in the two MCI groups was more reduced than that in the HC group, and the CDR/NPT MCI group exhibited additional disruption in the left inferior cingulum bundle. The results also demonstrated that neuropsychological measures have greater predictive value for changes in white matter beyond the contribution of an informant-based instrument alone. Overall, the findings confirm the utility of informant-based assessment in detecting microstructural brain changes in high-risk older adults, even before objective cognitive impairment is evident. The findings also suggest that combining the neuropsychological measures with the informant-based assessment provided the greatest predictive value in assessing white matter disruption. The essential role of the white matter measurement as a biomarker for detecting individuals at a high risk of developing dementia was highlighted. ? 2016 - IOS Press and the authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84970928407&doi=10.3233%2fJAD-150599&partnerID=40&md5=5a9e721ee2280be659b53d2382dddbeb https://scholars.lib.ntu.edu.tw/handle/123456789/519474 |
ISSN: | 1387-2877 | DOI: | 10.3233/JAD-150599 | SDG/關鍵字: | aged; Alzheimer disease; Article; brain region; cingulum (brain); clinical article; Clinical Dementia Rating; controlled study; female; gray matter; high risk patient; human; male; mild cognitive impairment; neuropsychological test; predictive value; priority journal; white matter; Alzheimer disease; brain; Cognition Disorders; image processing; memory; middle aged; nuclear magnetic resonance imaging; pathology; physiology; risk factor; very elderly; white matter; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition Disorders; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Neuropsychological Tests; Risk Factors; White Matter |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。