https://scholars.lib.ntu.edu.tw/handle/123456789/519490
標題: | CHRNA7 polymorphisms and response to cholinesterase inhibitors in Alzheimer's disease | 作者: | Weng P.-H. JEN-HAU CHEN TA-FU CHEN Sun Y. Wen L.-L. Yip P.-K. Chu Y.-M. YEN-CHING CHEN |
公開日期: | 2013 | 卷: | 8 | 期: | 12 | 起(迄)頁: | e84059 | 來源出版物: | PLoS ONE | 摘要: | Background: CHRNA7 encodes the α7 nicotinic acetylcholine receptor subunit, which is important to Alzheimer's disease (AD) pathogenesis and cholinergic neurotransmission. Previously, CHRNA7 polymorphisms have not been related to cholinesterase inhibitors (ChEI) response. Methods: Mild to moderate AD patients received ChEIs were recruited from the neurology clinics of three teaching hospitals from 2007 to 2010 (n = 204). Nine haplotype-tagging single nucleotide polymorphisms of CHRNA7 were genotyped. Cognitive responders were those showing improvement in the Mini-Mental State Examination score ?2 between baseline and 6 months after ChEI treatment. Results: AD women carrying rs8024987 variants [GG+GC vs. CC: adjusted odds ratio (AOR) = 3.62, 95% confidence interval (CI) = 1.47-8.89] and GG haplotype in block1 (AOR = 3.34, 95% CI = 1.38-8.06) had significantly better response to ChEIs (false discovery rate <0.05). These variant carriers using galantamine were 11 times more likely to be responders than female non-carriers using donepezil or rivastigmine. Conclusion: For the first time, this study found a significant association between CHRNA7 polymorphisms and better ChEI response. If confirmed by further studies, CHRNA7 polymorphisms may aid in predicting ChEI response and refining treatment choice. ? 2013 Weng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894214006&doi=10.1371%2fjournal.pone.0084059&partnerID=40&md5=775509b14faa7f1d626ffd33850d80c2 https://scholars.lib.ntu.edu.tw/handle/123456789/519490 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0084059 | SDG/關鍵字: | Aged; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Female; Follow-Up Studies; Genotype; Haplotypes; Humans; Male; Middle Aged; Polymorphism, Genetic; Prognosis; Retrospective Studies |
顯示於: | 醫學系 |
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