https://scholars.lib.ntu.edu.tw/handle/123456789/519566
標題: | Cerebral amyloid angiopathy in East and West | 作者: | Chen Y.-W. MING-JEN LEE Smith E.E. |
公開日期: | 2010 | 卷: | 5 | 期: | 5 | 起(迄)頁: | 403-411 | 來源出版物: | International Journal of Stroke | 摘要: | Cerebral amyloid angiopathy, a vasculopathy characterised by the deposition of amyloid fibrils in the arteries and arterioles in the cerebral cortex and meninges, has been reported to be associated with intracerebral haemorrhage and cognitive impairment in the elderly. Advances in neuroimaging and validation of the clinical diagnostic criteria aid in making a correct clinical diagnosis. Associations with Alzheimer's disease, asymptomatic microbleeds and white matter changes on neuroimaging have an influence on the clinical treatment for patients with probable cerebral amyloid angiopathy. Reviewing the reports from Asian countries, we found that patients with cerebral amyloid angiopathy have a strong age-related prevalence and a consistent association with dementia, but a weaker correlation with intracerebral haemorrhage, most likely due to a higher incidence of hypertensive intracerebral haemorrhage. Involvement of the occipital lobe arteries by CAA is common in all races and ethnicities, while frontal lobe arteries may be more frequently involved in the East compared to the West. The clinical impact of cerebral amyloid angiopathy on intracerebral haemorrhage and cognitive impairment could be increasingly obvious in Asian countries with ageing populations, especially with improving control of hypertension, the leading cause of intracerebral haemorrhage. ? 2010 The Authors. Journal compilation ? 2010 World Stroke Organization. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956251057&doi=10.1111%2fj.1747-4949.2010.00466.x&partnerID=40&md5=a5ab1cd79a74d54751c99409cf6c7c7f https://scholars.lib.ntu.edu.tw/handle/123456789/519566 |
ISSN: | 1747-4930 | DOI: | 10.1111/j.1747-4949.2010.00466.x | SDG/關鍵字: | acetylsalicylic acid; alpha 1 antichymotrypsin; amyloid beta protein; apolipoprotein E; hemosiderin; homotaurine; interleukin 33; membrane metalloendopeptidase; oxidized low density lipoprotein receptor 1; presenilin 1; transforming growth factor beta1; Alzheimer disease; Australia; Austria; brain artery; brain hemorrhage; Canada; China; clinical feature; cognitive defect; disease association; drug mechanism; frontal lobe; genetic polymorphism; groups by age; human; hypertension; Japan; nonhuman; nuclear magnetic resonance imaging; occipital lobe; pathogenesis; pathophysiology; prevalence; priority journal; review; United Kingdom; vascular amyloidosis; Asia; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Humans; Incidence; Prevalence |
顯示於: | 醫學系 |
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