Association between Helicobacter pylori infection and cognitive impairment in the elderly
Journal
Journal of the Formosan Medical Association
Journal Volume
117
Journal Issue
11
Pages
994-1002
Date Issued
2018
Author(s)
Abstract
Background/purpose: Helicobacter pylori (H. pylori) infection has been positively associated with cognitive impairment. However, previous studies have shown inconsistent findings. Methods: This cross-sectional study included 587 elderly participants (age ≧ 65) from the annual elderly health checkup program at the National Taiwan University Hospital from 2011 to 2013. Both global and domain-specific cognition were assessed using various neuropsychiatric tests. Multivariable linear regression and logistic regression models were utilized to assess the association between the serum H. pylori IgG level and cognitive impairment. Results: Compared with the lowest quartile of H. pylori IgG (Q1), the highest quartile (Q4) was associated with lower scores on verbal fluency-vegetables (β = ?0.24), domain-specific attention [digit span-forward: β = ?0.19; odds ratio (OR) = 1.83, 95% confidence interval (CI) = 1.03–3.24], and attention factors (β = ?0.20; OR= 2.67, 95% CI = 1.51–4.73). No significant association was observed for global cognition. Stratified analyses revealed that, among men, the highest quartile of serum H. pylori IgG (Q4) was associated with impaired scores on verbal fluency-vegetables (β = ?0.38; OR = 3.01, 95% CI = 1.42–6.38). Conclusion: Our findings disclosed a positive association between serum H. pylori level and cognitive impairment, which provides important information for the primary prevention of cognitive impairment through the eradication of H. pylori. ? 2017
SDGs
Other Subjects
immunoglobulin G; bacterium antibody; immunoglobulin G; aged; Article; attention; cognitive defect; confidence interval; cross-sectional study; disease association; female; Helicobacter infection; human; immunoglobulin blood level; major clinical study; male; multiple linear regression analysis; odds ratio; scoring system; blood; cognitive defect; Helicobacter infection; Helicobacter pylori; multivariate analysis; neuropsychological test; psychology; risk assessment; risk factor; self report; statistical model; Taiwan; Aged; Antibodies, Bacterial; Cognitive Dysfunction; Cross-Sectional Studies; Female; Helicobacter Infections; Helicobacter pylori; Humans; Immunoglobulin G; Linear Models; Logistic Models; Male; Multivariate Analysis; Neuropsychological Tests; Risk Assessment; Risk Factors; Self Report; Taiwan
Publisher
Elsevier B.V.
Type
journal article