https://scholars.lib.ntu.edu.tw/handle/123456789/520131
標題: | Neuropsychological profile in patients with early stage of Parkinson's disease in Taiwan | 作者: | Yu R.-L. RUEY-MEEI WU CHUN-HWEI TAI CHIN-HSIEN LIN Cheng T.-W. Hua M.-S. |
公開日期: | 2012 | 卷: | 18 | 期: | 10 | 起(迄)頁: | 1067-1072 | 來源出版物: | Parkinsonism and Related Disorders | 摘要: | Given the importance of early detection and intervention for disease management, determining the vulnerable neuropsychological function in patients with early-stage Parkinson's disease (PD) is a priority. Here, we describe the neuropsychological pattern in early-stage PD patients with mild cognitive impairment (PD-MCI) and dementia (PDD) in Taiwanese population. The neuropsychological performance of 94 patients with PD was compared with that of 84 healthy controls (HCs) and available normative data, using a comprehensive neuropsychological assessment including tests of executive, memory, psychomotor speed, attention, visuospatial, and language functions. Our results showed that PD patients performed significantly worse on executive function (i.e., category of card sorting) and psychomotor speed (i.e., processing speed index). Up to 46.8% were classified as PD-MCI and the majority of those having single-domain impairment (68.2%); 9.6% met the consensus diagnostic criteria for PDD. Accordingly, we suggest that early-stage PD patients have cognitive dysfunction predominately in the anterior brain. Further follow-up study to determine how many percent of PD-MCI develop PDD is important. The effect of neurocognitive rehabilitation on executive function is also valuable in the subsequence study. ? 2012 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870480997&doi=10.1016%2fj.parkreldis.2012.06.002&partnerID=40&md5=7474d2c7beb4ec724671bd15aec34a05 https://scholars.lib.ntu.edu.tw/handle/123456789/520131 |
ISSN: | 1353-8020 | DOI: | 10.1016/j.parkreldis.2012.06.002 | SDG/關鍵字: | adult; article; attention; cognitive rehabilitation; comprehension; concept formation; controlled study; dementia; depth perception; disease association; disease classification; executive function; female; human; language ability; major clinical study; male; memory; mild cognitive impairment; neuropsychology; Parkinson disease; priority journal; psychomotor performance; Taiwan; Aged; Attention; Cognition Disorders; Dementia; Early Diagnosis; Executive Function; Female; Follow-Up Studies; Humans; Language Tests; Male; Memory; Middle Aged; Mild Cognitive Impairment; Neuropsychological Tests; Parkinson Disease; Psychomotor Performance; Space Perception; Taiwan |
顯示於: | 醫學系 |
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