https://scholars.lib.ntu.edu.tw/handle/123456789/520266
標題: | Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer | 作者: | Su W.W.-Y. Chuang S.-L. Yen A.M.-F. Chen S.L.-S. Fann J.C.-Y. Chiu S.Y.-H. HAN-MO CHIU Su C.-W. Hsu C.-Y. Chen M.-K. Chen, Tony Hsiu Hsi CHENG-PING WANG YI-CHIA LEE |
公開日期: | 2019 | 出版社: | Blackwell Publishing Ltd | 卷: | 25 | 期: | 4 | 起(迄)頁: | 1067-1075 | 來源出版物: | Oral Diseases | 摘要: | Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ?18?years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE. ? 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063519898&doi=10.1111%2fodi.13080&partnerID=40&md5=4a5e2853410d217073ec2efd2ad9bf06 https://scholars.lib.ntu.edu.tw/handle/123456789/520266 |
ISSN: | 1354-523X | DOI: | 10.1111/odi.13080 | SDG/關鍵字: | alcohol; helium; adult; Article; cancer incidence; cancer risk; cancer screening; cigarette smoking; comparative study; controlled study; drinking behavior; esophagus cancer; female; hard palate; high risk patient; human; hypopharynx cancer; lip cancer; major clinical study; male; mass screening; mastication; mouth cancer; oropharynx cancer; pharynx cancer; primary tumor; priority journal; regression analysis; risk assessment; risk factor; second cancer; survival analysis; Taiwan; tongue cancer; aged; esophagus tumor; hypopharynx; hypopharynx tumor; middle aged; mouth tumor; pathology; second cancer; squamous cell carcinoma; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Humans; Hypopharyngeal Neoplasms; Hypopharynx; Male; Middle Aged; Mouth Neoplasms; Neoplasms, Second Primary; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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