https://scholars.lib.ntu.edu.tw/handle/123456789/520478
標題: | Assessing Whether the Association Between Sleep Apnea and Diabetes is Bidirectional | 作者: | Liu C.-L. CHI-SHIN WU |
關鍵字: | bidirectional association; longitudinal study; sleep apnea; type 2 diabetes mellitus | 公開日期: | 2017 | 卷: | 41 | 期: | 2 | 起(迄)頁: | 197-203 | 來源出版物: | Canadian Journal of Diabetes | 摘要: | Objectives To determine whether there is a bidirectional association between sleep apnea and diabetes mellitus. Methods We conducted longitudinal analyses of a population-based cohort over 12 years using Taiwan's national universal health insurance database. In analysis I, we included 102?355 individuals without type 2 diabetes mellitus at baseline and estimated the hazard ratio of incident diagnosis of type 2 diabetes mellitus for patients with and those without sleep apnea. In analysis II, we included 258?053 participants without sleep apnea at baseline and calculated the hazard ratio of developing sleep apnea for patients with and those without type 2 diabetes. Results In analysis I, the incidence rates of type 2 diabetes were 17.7 and 11.1 per 1000 person-years for patients with and those without sleep apnea, respectively. Patients with sleep apnea had an increased risk for diabetes (adjusted hazard ratio [aHR] = 1.33; 95% confidence interval [CI], 1.22 to 1.46). In analysis II, the risk for sleep apnea with diabetes was not statistically significant (aHR = 1.06; 95% CI, 0.98 to 1.16). These associations in both analyses did not substantively change after accounting for various latent periods. Conclusions Baseline sleep apnea is associated with incident type 2 diabetes; however, the presence of type 2 diabetes cannot predict the development of sleep apnea. ? 2016 Canadian Diabetes Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008392034&doi=10.1016%2fj.jcjd.2016.09.009&partnerID=40&md5=faef0a6ff37801d1f68aeaeaa5ceacb2 https://scholars.lib.ntu.edu.tw/handle/123456789/520478 |
ISSN: | 1499-2671 | DOI: | 10.1016/j.jcjd.2016.09.009 | SDG/關鍵字: | adult; age; aged; Article; body mass; cerebrovascular disease; chronic kidney failure; chronic liver disease; chronic lung disease; cohort analysis; comorbidity; congestive heart failure; disease association; disease severity; drug use; female; gender; health insurance; human; hyperlipidemia; hypertension; incidence; incidental finding; longitudinal study; major clinical study; male; mental disease; middle aged; non insulin dependent diabetes mellitus; obesity; patient risk; retrospective study; risk factor; sleep disordered breathing; adolescent; complication; non insulin dependent diabetes mellitus; Poisson distribution; proportional hazards model; sleep disordered breathing; very elderly; Adolescent; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Poisson Distribution; Proportional Hazards Models; Sleep Apnea Syndromes |
顯示於: | 流行病學與預防醫學研究所 |
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