Complications and mortality in patients with schizophrenia and diabetes: Populationbased cohort study
Journal
British Journal of Psychiatry
Journal Volume
207
Journal Issue
5
Date Issued
2015
Author(s)
Abstract
Background The longterm outcome of patients with both diabetes and schizophrenia remains unclear. Aims To explore whether having schizophrenia increases the risk of advanced complications and mortality in people with diabetes. Method This is a populationbased matched cohort study using Taiwan's National Health Insurance Research Database. A total of 11 247 participants with diabetes and schizophrenia and 11 247 participants with diabetes but not schizophrenia were enrolled. We used Cox proportional hazard models to determine the effect of schizophrenia on macrovascular and microvascular complications, and allcause mortality. Results The adjusted hazard ratios were 1.49 (95% CI 1.32-1.68) for macrovascular complications, 1.05 (95% CI 0.91-1.21) for microvascular complications and 3.68 (95% CI 3.21-4.22) for allcause mortality in patients with diabetes and schizophrenia compared with those patients with diabetes but not schizophrenia. Conclusions Patients with both diabetes and schizophrenia had an increased risk of macrovascular complications and allcause mortality but did not have statistically significant elevated risk of microvascular complications. Copyright ? 2015 The Royal College of Psychiatrists, unless otherwise stated.
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Other Subjects
antidepressant agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; creatinine; diuretic agent; glucose; hemoglobin A1c; lipid; adult; alcoholism; anxiety disorder; Article; cardiometabolic risk; chronic liver disease; cohort analysis; creatinine blood level; demography; diabetes mellitus; disease course; event free survival; female; glucose blood level; hazard ratio; hemodialysis; hemoglobin blood level; heritability; human; hyperglycemia; hypoglycemia; ischemic heart disease; kidney transplantation; laser coagulation; lipid blood level; major clinical study; major depression; male; medication compliance; middle aged; mortality; outpatient; peripheral vascular disease; predictive value; prescription; prevalence; schizophrenia; age distribution; cause of death; complication; factual database; Kaplan Meier method; non insulin dependent diabetes mellitus; proportional hazards model; retrospective study; risk factor; schizophrenia; sex ratio; statistical model; Taiwan; Adult; Age Distribution; Cause of Death; Databases, Factual; Diabetes Mellitus, Type 2; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Schizophrenia; Sex Distribution; Taiwan
Type
journal article