TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC-δ pathway
Journal
Journal of advanced research
Journal Volume
26
Pages
15
Date Issued
2020-11
Author(s)
Liao, Wei-Hao
Kung, Yi
Béra, Jean-Christophe
Inserra, Claude
Abstract
Numerous studies have shown the ability of low-energy acoustic waves such as focused ultrasound or shockwave to transiently open blood-brain barrier (BBB) and facilitate drug delivery to the brain. Preclinical and clinical evidences have well demonstrated the efficacy and safety in treating various brain disorders. However, the molecular mechanisms of acoustic waves on the BBB are still not fully understood.
Subjects
Acoustic waves; Blood–brain barrier; PKC-δ; Shockwave; TRPV4; Ultrasound
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Publisher
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