No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
Journal
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Journal Volume
153
Journal Issue
2
Pages
700-705
Date Issued
2010
Author(s)
Abstract
Robust associations between the dysbindin gene (DTNBP1) and schizophrenia have been demonstrated in many but not all samples, and evidence that this gene particularly predisposes to negative symptoms in this illness has been presented. The current study sought to replicate the previously reported negative symptom associations in an Irish case-control sample. Association between dysbindin and schizophrenia has been established in this cohort, and a factor analysis of the assessed symptoms yielded three factors, Positive, Negative, and Schneiderian. The sequential addition method was applied using UNPHASED to assess the relationship between these symptom factors and the high-risk haplotype. No associations were detected for any of the symptom factors indicating that the dysbindin risk haplotype does not predispose to a particular group of symptoms in this sample. Several possibilities, such as differing risk haplotypes, may explain this finding. ? 2009 Wiley-Liss, Inc.
SDGs
Other Subjects
dysbindin; messenger RNA; article; case control study; controlled study; factorial analysis; female; genetic association; genetic risk; haplotype; heterozygote detection; human; Ireland; major clinical study; male; negative syndrome; positive syndrome; priority journal; scoring system; single nucleotide polymorphism
Publisher
Blackwell Publishing Inc.
Type
journal article