Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study
Journal
Progress in neuro-psychopharmacology & biological psychiatry
Journal Volume
51
Pages
58
Date Issued
2014-06-03
Author(s)
Chuang, L C
Liu, J R
Huang, M C
Lin, S K
Sunny Sun, H
Abstract
Identification of genetic variants that influence bipolar I disorder (BPD-I) through genome-wide association (GWA) studies is limited in Asian populations. The current study aimed to identify novel common variants for BPD-I in an ethnically homogeneous Taiwanese sample using a multi-stage GWA study design.
Subjects
Bipolar disorder; Genome-wide association; Rank-based method
SDGs
Other Subjects
article; bipolar I disorder; controlled study; disease activity; disease association; gene; gene identification; gene locus; gene mapping; gene replication; genetic association; genetic marker; genetic variability; genotype; genotyping technique; human; KCNH7 gene; major clinical study; molecular dynamics; molecular pathology; MYST4 gene; NRXN3 gene; outcome assessment; patient assessment; promoter region; SEMA3D gene; single nucleotide polymorphism; syndrome delineation; adolescent; adult; aged; bipolar disorder; female; genetic association; genetic predisposition; genetics; male; middle aged; statistical model; Taiwan; young adult; histone acetyltransferase; KAT6B protein, human; KCNH7 protein, human; nerve protein; neurexin IIIalpha; potassium channel HERG; Sema3D protein, human; semaphorin; Adolescent; Adult; Aged; Bipolar Disorder; Ether-A-Go-Go Potassium Channels; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Histone Acetyltransferases; Humans; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Semaphorins; Taiwan; Young Adult
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Type
journal article