https://scholars.lib.ntu.edu.tw/handle/123456789/521201
標題: | Impact of cavitron ultrasonic surgical aspirator (CUSA) and bipolar radiofrequency device (Habib-4X) based hepatectomy for hepatocellular carcinoma on tumour recurrence and diseasefree survival | 作者: | KAI-WEN HUANG PO-HUANG LEE Kusano T. Reccia I. Jayant K. Habib N. |
公開日期: | 2017 | 出版社: | Impact Journals LLC | 卷: | 8 | 期: | 55 | 起(迄)頁: | 1-11 | 來源出版物: | Oncotarget | 摘要: | Background: The aim of this study was to evaluate the oncological outcomes of hepatocellular carcinoma patients undergoing liver resection using cavitron ultrasonic surgical aspirator (CUSA) or radiofrequency (RF) based device Habib-4X. Study Design: We prospectively analyzed the data of 280 patients who underwent liver resection for hepatocellular carcinoma at our institution from 2010-2012 with follow up till August 2016. The CUSA was used in the 163 patients whilst Habib-4X in 117 patients. The end points of analysis were oncological outcomes as disease recurrence, disease-free survival (DFS) and overall survival (OS) were estimated by the Kaplan-Meier method, which has been compared with all other existing literature on the survival study. Results: Compared with CUSA the reported incidence of recurrence was significantly lower, in Habib-4X group; p < 0.01. The median DFS was significantly better in Habib-4X group than CUSA group (50.80 vs 45.87 months, p = 0.03). The median OS was better in Habib-4X group than CUSA group (60.57 vs 57.17 months, p = 0.12) though the lesser difference in OS between the groups might be explained by the use of palliative therapies as TACE, percutaneous RFA, etc. in case of recurrence. Conclusions: RF based device Habib-4X, is safe and effective device for resection of hepatocellular carcinoma, in comparison to CUSA with better oncological outcomes, i.e., significantly lesser tumour recurrence and better DFS. This could be explained on the basis of systemic and local immunomodulatory effect involving induction of kupffer cells and effector CD-8 T cells that help in minimizing postoperative complications and bring more advantageous oncological outcomes. ? Huang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032939347&doi=10.18632%2foncotarget.21271&partnerID=40&md5=3235b2e91df811a0a8e0dccff93c18f8 https://scholars.lib.ntu.edu.tw/handle/123456789/521201 |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.21271 | SDG/關鍵字: | sorafenib; adult; Article; cancer palliative therapy; cancer radiotherapy; cancer recurrence; cancer size; CD8+ T lymphocyte; chemoembolization; clinical outcome; cohort analysis; controlled study; disease free survival; female; human; human tissue; immunomodulation; Kaplan Meier method; Kupffer cell; liver cell carcinoma; liver failure; liver resection; major clinical study; male; middle aged; multicenter study (topic); overall survival; patient safety; postoperative complication; postoperative hemorrhage; prospective study; radiofrequency ablation; sepsis; Taiwan |
顯示於: | 醫學系 |
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