https://scholars.lib.ntu.edu.tw/handle/123456789/521344
標題: | Gastrointestinal stromal tumor of the small intestine: A clinicopathologic study of 70 cases in the postimatinib era | 作者: | CHUN-CHIEH HUANG CHING-YAO YANG I-RUE LAI CHIUNG-NIEN CHEN PO-HUANG LEE MING-TSAN LIN |
公開日期: | 2009 | 卷: | 33 | 期: | 4 | 起(迄)頁: | 828-834 | 來源出版物: | World Journal of Surgery | 摘要: | Background: The small intestine, after the stomach, is the second most common primary site for gastrointestinal stromal tumors (GISTs). This study aimed to identify clinicopathologic prognostic factors of tumor recurrence and survival and to analyze the influence of imatinib and sunitinib for small-intestine GISTs. Methods: We reviewed the surgical experience of patients with small-intestine GISTs at National Taiwan University Hospital from January 1995 to March 2007. We analyzed the perioperative clinicopathologic data and treatment course. Results: Seventy patients were included. The tumor was local in 43 patients, advanced in 21 patients, and 6 had metastasis. The median size of the tumor was 6.5 cm. Forty-four patients had a mitotic rate of less than 5/50 high-power field. The 1-year and 5-year disease-free survival rates were 85 and 66.7%, respectively, while the 1-year and 5-year overall survival rates were 98.5 and 86.6%, respectively. There were 19 patients with recurrent disease and 6 patients died of intestinal GISTs. The response rate of imatinib and sunitinib were 73.3 and 60%, respectively. According to multivariate analysis for disease recurrence, only invasion status, tumor size, and mitotic rate are significant (P = 0.007, 0.035, 0.007 respectively). They are also associated with poor survival (P ? 0.001, 0.006, 0.002, respectively). Conclusions: The invasion status, size, and mitotic rate of tumor involve higher risk of recurrence and poor survival in small-intestine GISTs. The patients with recurrent small-intestine GISTs may have a lower mortality rate after using imatinib and sunitinib. ? 2009 Soci?t? Internationale de Chirurgie. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-62549132450&doi=10.1007%2fs00268-009-9918-4&partnerID=40&md5=1e1e753ba5b41f25924c4eced952718a https://scholars.lib.ntu.edu.tw/handle/123456789/521344 |
ISSN: | 0364-2313 | DOI: | 10.1007/s00268-009-9918-4 | SDG/關鍵字: | imatinib; sunitinib; adult; advanced cancer; aged; article; cancer invasion; cancer surgery; cancer survival; controlled study; female; gastrointestinal stromal tumor; histopathology; human; major clinical study; male; medical record review; metastasis; mitosis rate; mortality; perioperative period; prognosis; small intestine tumor; treatment response; tumor recurrence; tumor volume; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Disease-Free Survival; Duodenal Neoplasms; Female; Gastrointestinal Agents; Gastrointestinal Stromal Tumors; Humans; Ileal Neoplasms; Intestinal Neoplasms; Jejunal Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Retrospective Studies |
顯示於: | 醫學系 |
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