Plasma free amino acid profile in cancer patients
Journal
Seminars in Cancer Biology
Journal Volume
15
Journal Issue
4
Pages
267-276
Date Issued
2005
Author(s)
Abstract
Redistribution or translocation of plasma free amino acids (PFAAs) to support visceral or tumor protein synthesis is an essential feature in cancer patients. An abnormal PFAA profile might be presented via the total reflection of cancer-induced protein metabolism in tumors, skeletal muscle and the liver in cancer patients. Clinical data from 13 studies have demonstrated a cancer-related PFAA profile, especially in digestive organ cancers. The PFAA profile can differ between the early and late stages of cancer. The profile is also affected by the type of cancer. Therefore, it is postulated that a detailed analysis of the PFAA profile may serve as one of the biological markers for cancer patients. ? 2005 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
amino acid; biological marker; tumor protein; amino acid blood level; cancer; cancer staging; digestive system; human; liver; nutrition; protein localization; protein metabolism; protein synthesis; review; skeletal muscle; Amino Acids; Humans; Neoplasms
Type
Review