https://scholars.lib.ntu.edu.tw/handle/123456789/521493
標題: | Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma | 作者: | Chen J.-D. CHUN-JEN LIU PO-HUANG LEE PEI-JER CHEN Lai M.-Y. JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2004 | 出版社: | W.B. Saunders | 卷: | 2 | 期: | 1 | 起(迄)頁: | 64-71 | 來源出版物: | Clinical Gastroenterology and Hepatology | 摘要: | Background & Aims: Hepatitis B virus (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC), compared with genotype B. This study aims to investigate whether HBV genotypes influence the clinicopathologic features and long-term prognosis of patients after curative resection of HCC. Methods: Stored serum samples from 62 patients with HBV-related HCC were tested for HBV genotype using a molecular method. Results: Sixty of 62 patients (96.8%) undergoing curative resection of HCC were infected with genotype B or C. Concomitant cirrhosis was encountered more frequently in patients with genotype C. During a mean follow-up period of 26.3 ± 9.8 months, patients with genotype B had a lower overall tumor recurrence rate than those with genotype C (22% vs. 46%; P = 0.04). Stepwise multiple Cox proportional hazards regression analysis showed that multiplicity of tumor (hazard ratio, 6.84; 95% confidence interval [CI], 1.45-32.2; P = 0.02) was associated with tumor recurrence, whereas genotype C and age were associated with borderline significance (P = 0.06). Stratified analysis showed that genotype C was still associated with tumor recurrence in cirrhotic patients with borderline significance by univariate analysis (hazard ratio, 3.8; 95% CI, 0.84-17.6; P = 0.07). However, cumulative 2-year survival rates were similar between patients with genotype B and C (92% vs. 85%; P = 0.23). Conclusions: Our data suggest that patients with HCC with genotype C have a greater tumor recurrence rate after curative resection of HCC compared with those with genotype B. Prolonged follow-up is needed to clarify the impact of HBV genotype on postoperative outcome. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984577957&doi=10.1016%2fS1542-3565%2803%2900293-3&partnerID=40&md5=a738199ecbed749c26396888b7e2baf7 https://scholars.lib.ntu.edu.tw/handle/123456789/521493 |
ISSN: | 1542-3565 | DOI: | 10.1016/S1542-3565(03)00293-3 | SDG/關鍵字: | adult; aged; article; blood sampling; cancer recurrence; cancer surgery; cancer survival; confidence interval; controlled study; female; follow up; genotype; hepatitis B; hepatitis C; human; human tissue; liver cell carcinoma; liver cirrhosis; liver resection; major clinical study; male; statistical analysis; survival rate; virus carcinogenesis |
顯示於: | 醫學系 |
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