https://scholars.lib.ntu.edu.tw/handle/123456789/521794
Title: | Estimating genotype relative risks in case-parental control studies: A Mantel-Haenszel approach | Authors: | Chang C.-H. WEN-CHUNG LEE |
Keywords: | Case-parental control study; Epidemiologic methodology; Genetic epidemiology; Genotype relative risks; Mantel-Haenszel method | Issue Date: | 2000 | Journal Volume: | 19 | Journal Issue: | 6 | Start page/Pages: | 485-490 | Source: | Chinese Journal of Public Health | Abstract: | Objectives: Epidemiologists often study the relationship between a susceptibility gene and a disease using the case-control design. Due to stratification/admixture that may exist in the study population, the conventional case-control design may lead to biased estimation of 'genotype relative risks'(GRRs). This problem can be circumvented by using the 'case-parental control design' instead. Under this design, there have been three non-iterative methods for estimating GRRs proposed in the literature. Here we propose a new non-iterative method using the Mantel-Haenszel(M-H) concept. Methods: The above four methods have similar formula apart from the weighting constants. The weighting constants used in the M-H method are 1.5. Results: Monte-Carlo simulation shows that the above four methods all produce estimates that are approximately unbiased. However, the M-H method has the smallest variance and hence is the most stable among the four methods. Conclusions: The M-H method is simple to calculate and more stable than the other three non-iterative methods for the estimation of the GRRs in the case-parental control study. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034448220&partnerID=40&md5=6f596f10b2bab82bff972f62a9c8e60b https://scholars.lib.ntu.edu.tw/handle/123456789/521794 |
ISSN: | 1023-2141 | SDG/Keyword: | article; case control study; genetic disorder; genetic risk; genetic susceptibility; genotype; human; risk factor; simulation |
Appears in Collections: | 流行病學與預防醫學研究所 |
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