https://scholars.lib.ntu.edu.tw/handle/123456789/521803
標題: | False appearance of gene-environment interactions in genetic association studies | 作者: | Su Y.-S. WEN-CHUNG LEE |
公開日期: | 2016 | 出版社: | Lippincott Williams and Wilkins | 卷: | 95 | 期: | 9 | 來源出版物: | Medicine (United States) | 摘要: | Under the assumption of gene-environment independence, unknown/unmeasured environmental factors, irrespective of what they may be, cannot confound the genetic effects. This may lead many people to believe that genetic heterogeneity across different levels of the studied environmental exposure should only mean gene-environment interaction-even though other environmental factors are not adjusted for. However, this is not true if the odds ratio is the effect measure used for quantifying genetic effects. This is because the odds ratio is a "noncollapsible" measure-a marginal odds ratio is not a weighted average of the conditional odds ratios, but instead has a tendency toward the null. In this study, the authors derive formulae for gene-environment interaction bias due to noncollapsibility. They use computer simulation and real data example to show that the bias can be substantial for common diseases. For genetic association study of nonrare diseases, researchers are advised to use collapsible measures, such as risk ratio or peril ratio. Copyright ? 2016 Wolters Kluwer Health, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962506733&doi=10.1097%2fMD.0000000000002743&partnerID=40&md5=bb8de4805ef749b552105970e8227566 https://scholars.lib.ntu.edu.tw/handle/123456789/521803 |
ISSN: | 0025-7974 | DOI: | 10.1097/MD.0000000000002743 | SDG/關鍵字: | Article; computer simulation; environmental exposure; environmental factor; genetic association; genotype environment interaction; heredity; human; measurement error; priority journal; computer simulation; epidemiology; genetic association study; genetics; macular degeneration; odds ratio; procedures; statistical bias; statistics and numerical data; complement factor H; Bias (Epidemiology); Complement Factor H; Computer Simulation; Confounding Factors (Epidemiology); Gene-Environment Interaction; Genetic Association Studies; Humans; Macular Degeneration; Odds Ratio |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。