Relationship between pancreatic cancer-associated diabetes and cachexia
Journal
Journal of cachexia, sarcopenia and muscle
Journal Volume
11
Journal Issue
4
Pages
899
Date Issued
2020-08
Author(s)
Chen, Peng-Ruei
Huang, Cheng-Chieh
Chang, Yen-Tzu
Huang, Bo-Shih
Abstract
Pancreatic cancer-associated diabetes mellitus (PCDM) is a paraneoplastic phenomenon characterized by worsening hyperglycaemia and weight loss. Galectin-3 and S100A9, mediators of PCDM, have pro-inflammatory functions and might thereby induce systemic inflammation and cachexia. We aimed to examine whether PCDM directly mediates cachexia.
Subjects
Cachexia; Diabetes; Pancreatic cancer; Sarcopenia
SDGs
Other Subjects
calgranulin B; galectin 3; glucose; hemoglobin A1c; adult; Article; body mass; body weight loss; cachexia; cancer size; cancer staging; clinical feature; diabetes mellitus; diabetic patient; disease association; fasting; female; glucose blood level; human; hyperglycemia; logistic regression analysis; major clinical study; male; middle aged; muscle mass; pancreas cancer; paraspinal muscle; primary tumor; priority journal; protein blood level; sarcopenia; skeletal muscle; cachexia; complication; diabetes mellitus; pancreas tumor; pathophysiology; Cachexia; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms
Publisher
WILEY
Type
journal article