Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/522346
Title: Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons
Authors: Kuo L.-C.
Song Y.-Q.
CHIEN-AN YAO 
Cheng I.H.
Chien C.-T.
Lee G.-C.
Yang W.-C.
Lin Y.
Keywords: Alzheimer's disease; amyloid β; ginkgolide A; glutamate receptors; herbal medicines; memantine
Issue Date: 2019
Publisher: American Chemical Society
Journal Volume: 67
Journal Issue: 1
Start page/Pages: 81-89
Source: Journal of Agricultural and Food Chemistry
Abstract: 
Utilizing the N-methyl-d-aspartate (NMDA) receptor antagonist as a strategy, memantine is the only agent available for clinically treating mild to severe Alzheimer's disease (AD). Our aim was to develop novel similar herb-based drugs. Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid β (Aβ)-induced abnormal depolarization in mouse primary cortical neurons. Using receptor agonists, it was determined that GA inhibits both NMDA receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Furthermore, the Aβ-induced increase in c-Jun N-terminal kinase phosphorylation in neurons was prevented by GA. Body weight, glutamate oxaloacetate transaminase, glutamic-pyruvic transaminase, liver histology, and kidney histology were similar when the wild-type/AD animal model mice with and without GA treatment were compared. This pure compound improves the memory of wild-type mice. Our findings indicate that GA has great potential clinically for the treatment of AD because it might target NMDA receptors just like memantine. ? 2018 American Chemical Society.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059366147&doi=10.1021%2facs.jafc.8b04514&partnerID=40&md5=3de146b78ec64de6d6d581cdb0a11a1a
https://scholars.lib.ntu.edu.tw/handle/123456789/522346
ISSN: 0021-8561
DOI: 10.1021/acs.jafc.8b04514
SDG/Keyword: Depolarization; Diagnosis; Glycoproteins; Histology; Mammals; Neurons; Alzheimer's disease; Ginkgolide A; Glutamate receptor; Herbal medicines; Memantine; Neurodegenerative diseases; amyloid beta protein; Ginkgo biloba extract; ginkgolide; ginkgolide A; lactone; n methyl dextro aspartic acid receptor; neuroprotective agent; plant extract; Alzheimer disease; animal; brain cortex; C57BL mouse; chemistry; cytology; drug effect; genetics; Ginkgo biloba; human; male; metabolism; mouse; nerve cell; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Plant Extracts; Receptors, N-Methyl-D-Aspartate
[SDGs]SDG3
Appears in Collections:醫學系

Show full item record

SCOPUSTM   
Citations

17
checked on May 18, 2023

WEB OF SCIENCETM
Citations

17
checked on May 20, 2023

Page view(s)

72
checked on May 10, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback