|Title:||Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons||Authors:||Kuo L.-C.
|Keywords:||Alzheimer's disease; amyloid β; ginkgolide A; glutamate receptors; herbal medicines; memantine||Issue Date:||2019||Publisher:||American Chemical Society||Journal Volume:||67||Journal Issue:||1||Start page/Pages:||81-89||Source:||Journal of Agricultural and Food Chemistry||Abstract:||
Utilizing the N-methyl-d-aspartate (NMDA) receptor antagonist as a strategy, memantine is the only agent available for clinically treating mild to severe Alzheimer's disease (AD). Our aim was to develop novel similar herb-based drugs. Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid β (Aβ)-induced abnormal depolarization in mouse primary cortical neurons. Using receptor agonists, it was determined that GA inhibits both NMDA receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Furthermore, the Aβ-induced increase in c-Jun N-terminal kinase phosphorylation in neurons was prevented by GA. Body weight, glutamate oxaloacetate transaminase, glutamic-pyruvic transaminase, liver histology, and kidney histology were similar when the wild-type/AD animal model mice with and without GA treatment were compared. This pure compound improves the memory of wild-type mice. Our findings indicate that GA has great potential clinically for the treatment of AD because it might target NMDA receptors just like memantine. ? 2018 American Chemical Society.
|ISSN:||0021-8561||DOI:||10.1021/acs.jafc.8b04514||SDG/Keyword:||Depolarization; Diagnosis; Glycoproteins; Histology; Mammals; Neurons; Alzheimer's disease; Ginkgolide A; Glutamate receptor; Herbal medicines; Memantine; Neurodegenerative diseases; amyloid beta protein; Ginkgo biloba extract; ginkgolide; ginkgolide A; lactone; n methyl dextro aspartic acid receptor; neuroprotective agent; plant extract; Alzheimer disease; animal; brain cortex; C57BL mouse; chemistry; cytology; drug effect; genetics; Ginkgo biloba; human; male; metabolism; mouse; nerve cell; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Plant Extracts; Receptors, N-Methyl-D-Aspartate
|Appears in Collections:||醫學系|
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