https://scholars.lib.ntu.edu.tw/handle/123456789/522346
Title: | Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons | Authors: | Kuo L.-C. Song Y.-Q. CHIEN-AN YAO Cheng I.H. Chien C.-T. Lee G.-C. Yang W.-C. Lin Y. |
Keywords: | Alzheimer's disease; amyloid β; ginkgolide A; glutamate receptors; herbal medicines; memantine | Issue Date: | 2019 | Publisher: | American Chemical Society | Journal Volume: | 67 | Journal Issue: | 1 | Start page/Pages: | 81-89 | Source: | Journal of Agricultural and Food Chemistry | Abstract: | Utilizing the N-methyl-d-aspartate (NMDA) receptor antagonist as a strategy, memantine is the only agent available for clinically treating mild to severe Alzheimer's disease (AD). Our aim was to develop novel similar herb-based drugs. Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid β (Aβ)-induced abnormal depolarization in mouse primary cortical neurons. Using receptor agonists, it was determined that GA inhibits both NMDA receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Furthermore, the Aβ-induced increase in c-Jun N-terminal kinase phosphorylation in neurons was prevented by GA. Body weight, glutamate oxaloacetate transaminase, glutamic-pyruvic transaminase, liver histology, and kidney histology were similar when the wild-type/AD animal model mice with and without GA treatment were compared. This pure compound improves the memory of wild-type mice. Our findings indicate that GA has great potential clinically for the treatment of AD because it might target NMDA receptors just like memantine. ? 2018 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059366147&doi=10.1021%2facs.jafc.8b04514&partnerID=40&md5=3de146b78ec64de6d6d581cdb0a11a1a https://scholars.lib.ntu.edu.tw/handle/123456789/522346 |
ISSN: | 0021-8561 | DOI: | 10.1021/acs.jafc.8b04514 | SDG/Keyword: | Depolarization; Diagnosis; Glycoproteins; Histology; Mammals; Neurons; Alzheimer's disease; Ginkgolide A; Glutamate receptor; Herbal medicines; Memantine; Neurodegenerative diseases; amyloid beta protein; Ginkgo biloba extract; ginkgolide; ginkgolide A; lactone; n methyl dextro aspartic acid receptor; neuroprotective agent; plant extract; Alzheimer disease; animal; brain cortex; C57BL mouse; chemistry; cytology; drug effect; genetics; Ginkgo biloba; human; male; metabolism; mouse; nerve cell; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Plant Extracts; Receptors, N-Methyl-D-Aspartate [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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