https://scholars.lib.ntu.edu.tw/handle/123456789/522684
標題: | Prognostic factors affecting the outcome of brain metastases from breast cancer | 作者: | Liu M.-T. CHANG-YAO HSIEH Wang A.-Y. Chang T.-H. Pi C.-P. Huang C.-C. CHAO-YUAN HUANG Liou C.-H. |
公開日期: | 2006 | 卷: | 14 | 期: | 9 | 起(迄)頁: | 936-942 | 來源出版物: | Supportive Care in Cancer | 摘要: | Goals of work: The purpose of this study is to analyze the overall survival rate of patients with brain metastases from breast cancer and to determine prognostic factors affecting outcomes of these patients. Patients and methods: From July 1988 to December 2004, 48 female patients with brain metastases from breast cancer underwent full-dose whole-brain radiotherapy (WBRT). In these patients we evaluated the significance of the following factors in predicting the survival rate after WBRT: age, extracranial metastases, number of brain metastases, total dose of WBRT, Karnofsky performance status (KPS), and Radiation Therapy Oncology Group recursive partitioning analysis (RPA) class. Results: The median overall survival rate was 7.3 months. The 1- and 2-year overall survival rates were 37 and 20%, respectively. In univariate analysis, KPS (p<0.0001), number of lesions of brain metastases (p=0.0149), age (p=0.0452), and RPA class (p<0.0001) were statistically significant prognostic factors for overall survival. In multivariate analysis, KPS (p<0.001) and number of brain metastases (p=0.039) were significant prognostic factors for overall survival. Conclusions: Survival of breast cancer patients with brain metastases treated with WBRT is poor. To improve survival, enrollment of more patients with brain metastases from breast cancer for prospective trials involving a multimodality approach that combines radiation and systemic therapies based on appropriate patient triage is warranted. ? Springer-Verlag 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33747344249&doi=10.1007%2fs00520-006-0029-6&partnerID=40&md5=4ce8729a39a2ed7c3c52d807fe067317 https://scholars.lib.ntu.edu.tw/handle/123456789/522684 |
ISSN: | 0941-4355 | DOI: | 10.1007/s00520-006-0029-6 | SDG/關鍵字: | adult; article; brain metastasis; breast cancer; cancer radiotherapy; cancer survival; clinical article; controlled study; female; human; Karnofsky Performance Status; priority journal; prognosis; radiation dose; radiation therapy oncology group recursive partitioning analysis; scoring system; survival rate; whole brain radiotherapy; Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Dose Fractionation; Female; Follow-Up Studies; Humans; Karnofsky Performance Status; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Prognosis; Survival Rate; Taiwan; Time Factors; Treatment Outcome |
顯示於: | 醫學系 |
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