Total urinary isothiocyanates, glutathione S-transferase M1 genotypes, and lung cancer risk: A preliminary nested case-control study in Taiwan
Journal
Journal of Medical Sciences
Journal Volume
25
Journal Issue
1
Pages
21-25
Date Issued
2005
Author(s)
Abstract
Background: This study was conducted as a preliminary examination of the relationship between urinary ITC levels and lung cancer risk, and the effect of polymorphisms in the GSTM1 gene on this ITC-associated risk. Methods: A nested case-control study using a urinary biomarker of total dietary intake of ITCs was performed. Thirty histologically confirmed lung cancer cases, ascertained by computerized linkage of data with information from the National Cancer Registry, were randomly selected from lung cancer cases in a 7-township cancer-screening cohort in Taiwan. Two cancer-free controls were matched to each case by age (±2 years), sex, residence, and date of collection of biologic specimens (±3 months). Total urinary ITC was measured by high-performance liquid chromatography, and homozygous deletion of the GSTM1 gene was determined by PCR. Results: The percentage of individuals with undetectable ITC in the urine was 20% for cases and 11.7% for controls. Individuals with detectable ITC had a 50% decreased lung cancer risk (adjusted OR=0.5, 95% CI=0.2-1.7). Furthermore, the decreased risk associated with detectable urinary ITC was restricted to individuals with a GSTM1-null genotype. Conclusions: ITCs appear to be associated with a non-statistically significant reduced lung cancer risk in this Chinese population in Taiwan. The GST metabolic genotype modified the protective effect of ITCs on lung cancer risk. Further studies are needed to confirm the findings from this exploratory study. Copyright ?2005 JMS.
Subjects
Glutathione S-transferase M1; Isothiocyanates; Lung cancer; Nested case-control study
SDGs
Other Subjects
glutathione transferase M1; isothiocyanic acid; adult; article; cancer registry; cancer risk; cancer screening; cancer susceptibility; case control study; Chinese; cohort analysis; controlled study; female; gene deletion; genetic linkage; genetic polymorphism; genotype; high performance liquid chromatography; human; human tissue; lung carcinoma; major clinical study; male; null allele; polymerase chain reaction; population research; protein urine level; Taiwan
Type
journal article