https://scholars.lib.ntu.edu.tw/handle/123456789/522732
標題: | Intra-thoracic failure pattern and survival status following 3D conformal radiotherapy for non-small cell lung cancer: A preliminary report | 作者: | Chien C.-R. Chen S.-W. CHANG-YAO HSIEH Liang J.-A. Yang S.-N. CHAO-YUAN HUANG Lin F.-J. |
公開日期: | 2001 | 出版社: | Oxford University Press | 卷: | 31 | 期: | 2 | 起(迄)頁: | 55-60 | 來源出版物: | Japanese Journal of Clinical Oncology | 摘要: | Background: To study the intra-thoracic failure pattern, clinical target volume (CTV) and survival status following 3D conformal radiotherapy (3DCRT) boost for non-small cell lung cancer (NSCLC). Methods: From May 1994 through June 1998, 33 patients (26 male, seven female) with NSCLC were treated with a complete course of radiotherapy (RT) in our institute. Group A included 10 patients receiving radical operation and adjuvant postoperative RT. The other 23 patients (groups B and C) received definitive radiotherapy as local treatment. Among them there were seven cases as group B (stage I-II) and 16 cases as group C (stage III). Fifteen (15/33) patients received chemotherapy. The radiotherapy strategy constituted conventional AP/PA radiotherapy (RT) 19.8-45 Gy (median 39.6 Gy) plus 3DCRT boost 6-34.2 Gy (median 20 Gy). The median total tumor dose was 59.6 Gy (ranging from 39.8 to 64.8 Gy). Patients were followed up regularly (6/33) or until their death (27/33). Nineteen patients received follow-up chest computed tomography (CT). The relationship between intra-thoracic failure found by chest CT and the initial RT and boost RT fields was analyzed. Local failure was defined as one of the following: clinical disease progression, CXR progression or relapse noted by CT. The overall survival (OS) and local failure free survival (LFF) were obtained using the Kaplan-Meier method. Results: Sixteen intra-thoracic failures were noted in 15 follow-up chest CT examinations, which included nine in-field relapses, three partial in-field relapses and four out-field relapses. The 2-year OS and LFF for groups A, B and C were 78.8/59.2, 14.2/16.7 and 6.2/7.1% respectively. RTOG grade III/IV complications included one pneumothorax (RTOG grade III). Conclusion: Our retrospective study showed that selective omission of contralateral mediastinal lymph node station irradiation may be appropriate in RT for NSCLC. Chest wall and pleural relapses may not be a negligible cause of intra-thoracic failure after RT for NSCLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035072919&doi=10.1093%2fjjco%2fhye015&partnerID=40&md5=6ee37be752edff1619d7fa86af5999a5 https://scholars.lib.ntu.edu.tw/handle/123456789/522732 |
ISSN: | 0368-2811 | DOI: | 10.1093/jjco/hye015 | SDG/關鍵字: | adult; aged; article; cancer adjuvant therapy; cancer grading; cancer growth; cancer recurrence; cancer survival; clinical article; computer assisted radiotherapy; computer assisted tomography; female; follow up; human; lung non small cell cancer; lung surgery; lymph node irradiation; male; metastasis; pneumothorax; retrospective study; target cell; treatment failure; treatment outcome; treatment planning; X ray |
顯示於: | 醫學系 |
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