https://scholars.lib.ntu.edu.tw/handle/123456789/522742
標題: | Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma | 作者: | WEN-FANG CHENG CHIEN-NAN LEE Chu J.-S. CHI-AN CHEN Chen T.-M. Shau W.-Y. CHANG-YAO HSIEH FON-JOU HSIEH |
公開日期: | 1999 | 卷: | 85 | 期: | 3 | 起(迄)頁: | 651-657 | 來源出版物: | Cancer | 摘要: | BACKGROUND. The importance of angiogenesis now is well recognized. Conventionally, tumor angiogenesis is assessed by determination of microvessel density (MVD) in the surgical specimen. This study examines tumor angiogenesis using power Doppler ultrasound and a quantitative image processing system. The authors hope to develop an in vivo and noninvasive method for quantitating tumor angiogenesis. METHODS. Thirty-five patients with FIGO Stage IB-IIA cervical carcinoma exhibiting visible cervical tumors by transvaginal ultrasound were included in this study. All patients underwent radical abdominal hysterectomy and pelvic lymph node dissection. Transvaginal power Doppler ultrasound was performed before surgery to search for blood flow signals from the tumor. The intratumoral vascularity index (VI) and resistance index (RI) were calculated. The VI was defined as the number of colored pixels divided by the number of total pixels in the defined tumor section. Maximal VI and minimal RI of a certain tumor were used for analysis. Clinical and pathologic data also were recorded. The MVD of the excised tumor was assessed immunohistochemically using a monoclonal antibody against CD34. RESULTS. Significantly higher VI values were noted in Stage II tumors compared with Stage I tumors (19.01 ± 10.90% vs. 9.09 ± 6.59%; P = 0.008), tumors invading + 50% of the cervical stroma compared with tumors invading < 50% of the cervical stroma (13.20 ± 8.20% vs. 5.72 ± 5.00%; P = 0.003), tumors with lymphovascular emboli compared with tumors without lymphovascular emboli (17.28 ± 8.26% vs. 6.98 ± 5.09%; P = 0.001), and tumors with pelvic lymph node metastases compared with tumors without pelvic lymph node metastases (26.16 ± 7.88% vs. 8.00 ± 4.95%; P = 0.021). None of the variable mentioned earlier showed a significant difference in terms of the RI values. No correlation was noted between intratumoral RI and VI in respective tumors (P = 0.53). Analysis of VI revealed linear regression with regard to tumor size (P < 0.001, correlation coefficient [r] = 0.586) and depth of stromal invasion (P = 0.002, r = 0.497). In addition, the MVD exhibited a linear relation with VI (P = 0.006, r = 0.454), tumor size [P = 0.005, r = 0.465), and depth of stromal invasion (P = 0.009, r = 0.436) using simple regression analysis. No correlation could be found between MVD and RI. CONCLUSIONS. In cervical carcinoma, intratumoral VI assessment by power Doppler ultrasound and quantitative image processing system showed better correlation with tumor stage, tumor size, and pathologic findings including depth of stromal invasion, lymphovascular emboli, and pelvic lymph node metastases than intratumoral RI. The in vivo indicator of angiogenic activity (VI) is well correlated with the conventional indicator of tumor angiogenic activity (MVD). Thus, VI could be a useful parameter for the in vivo assessment of global tumor angiogenesis. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033083125&doi=10.1002%2f%28SICI%291097-0142%2819990201%2985%3a3%3c651%3a%3aAID-CNCR15%3e3.0.CO%3b2-9&partnerID=40&md5=65a7e05f54ba519ac6edfa4d9c2627e4 https://scholars.lib.ntu.edu.tw/handle/123456789/522742 |
ISSN: | 0008-543X | DOI: | 10.1002/(SICI)1097-0142(19990201)85:3<651 | SDG/關鍵字: | adult; angiogenesis; article; cancer size; cancer staging; clinical article; color ultrasound flowmetry; human; human tissue; priority journal; tumor blood flow; uterine cervix carcinoma; vascularization; Adenocarcinoma; Adult; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Female; Humans; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Neovascularization, Pathologic; Regional Blood Flow; Ultrasonography, Doppler; Uterine Cervical Neoplasms |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。