https://scholars.lib.ntu.edu.tw/handle/123456789/522943
標題: | Contributors, risk associates, and complications of frailty in patients with chronic kidney disease: a scoping review | 作者: | Wu P.Y. CHIA-TER CHAO DING-CHENG CHAN JENQ-WEN HUANG KUAN-YU HUNG |
公開日期: | 2019 | 出版社: | SAGE Publications Ltd | 卷: | 10 | 來源出版物: | Therapeutic Advances in Chronic Disease | 摘要: | Frailty exhibits diverse influences on health-related outcomes and represents a surrogate of increased susceptibility to harmful injuries. Patients with chronic kidney disease (CKD) are at a higher risk of accelerated biologic aging, and, in this population, the concept of frailty emerges as an instrumental measurement of physiologic reserves. However, a comprehensive description of known independent contributors to, and risk associates of, frailty in these patients remain unavailable. In the present review, original studies up to 28 February 2019 that assessed frailty in patients with all stages of CKD were retrieved and reviewed, with results extracted and summarized. By pooling 62 original investigations, 58.1% and 49.1% used cohort and cross-sectional designs, respectively. Dialysis-dependent end-stage renal disease patients (n = 39; 62.9%) were the most commonly examined population, followed by those with nondialysis CKD (n = 12; 19.4%) and those receiving renal transplantation (n = 11; 17.7%). Contributors to frailty in CKD patients included sociodemographic factors, smoking, CKD severity, organ-specific comorbidities, depression, hypoalbuminemia, and low testosterone levels. Conversely, the development of frailty was potentially associated with the emergence of cardiometabolic, musculoskeletal, and cerebral complications; mental distress; and a higher risk of subsequent functional and quality-of-life impairment. Moreover, frailty in CKD patients increased healthcare utilization and consistently elevated mortality among affected ones. Based on the multitude of contributors to frailty and its diverse health influences, a multifaceted approach to manage CKD patients with frailty is needed, and its potential influences on outcomes besides mortality need to be considered. ? The Author(s), 2019. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073262901&doi=10.1177%2f2040622319880382&partnerID=40&md5=586de2bbcbe9b670349698182b1136bc https://scholars.lib.ntu.edu.tw/handle/123456789/522943 |
ISSN: | 2040-6223 | DOI: | 10.1177/2040622319880382 | SDG/關鍵字: | C reactive protein; hemoglobin; interleukin 6; parathyroid hormone; testosterone; vitamin D; aging; blood pressure; cardiometabolic risk; cerebrovascular disease; chronic kidney failure; clinical feature; comorbidity; depression; disease severity; electrocardiography; end stage renal disease; frailty; health care utilization; hospitalization; human; hypoalbuminemia; inflammation; kidney function; kidney transplantation; malnutrition; metabolic disorder; mortality; musculoskeletal disease; outcome assessment; peritoneal dialysis; pleiotropy; priority journal; quality of life; renal replacement therapy-dependent renal disease; Review; risk factor; smoking |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。