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  1. NTU Scholars
  2. 醫學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/522963
Title: Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review
Authors: Beaudart C.
Dawson A.
Shaw S.C.
Harvey N.C.
Kanis J.A.
Binkley N.
Reginster J.Y.
Chapurlat R.
DING-CHENG CHAN 
Bruyère O.
Rizzoli R.
Cooper C.
Dennison E.M.
the IOF-ESCEO Sarcopenia Working Group, Adib G.
Brandi M.L.
Chevalley T.
Clark P.
Dawson-Hughes B.
El Maghraoui A.
Engelke K.
Fielding R.
Foldes A.J.
Gugliemi G.
Kaufman J.M.
Larijani B.
Lems W.
van Loon L.J.C.
Lyritis G.P.
Maggi S.
Masi L.
McCloskey E.
Messina O.D.
Papaioannou A.
Szulc P.
Veronese N.
Keywords: Dietary; Intervention; Physical activity; Sarcopenia
Issue Date: 2017
Publisher: Springer London
Journal Volume: 28
Journal Issue: 6
Start page/Pages: 1817-1833
Source: Osteoporosis International
Abstract: 
Summary: This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65?years and older. However, any interactive effect of dietary supplementation appears to be limited. Introduction: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. They concluded that further studies were needed to provide evidence upon which public health and clinical recommendations could be based. The purpose of the present work was to update the prior systematic review and include studies published up to October 2015. Methods: Using the electronic databases MEDLINE and EMBASE, we identified RCTs which assessed the combined effect of exercise training and nutritional supplementation on muscle strength, muscle mass, or physical performance in subjects aged 60?years and over. Study selection and data extraction were performed by two independent reviewers. Results: The search strategy identified 21 additional RCTs giving a total of 37 RCTs. Studies were heterogeneous in terms of protocols for physical exercise and dietary supplementation (proteins, essential amino acids, creatine, β-hydroxy-β-methylbuthyrate, vitamin D, multi-nutrients, or other). In 79% of the studies (27/34 RCTs), muscle mass increased with exercise but an additional effect of nutrition was only found in 8 RCTs (23.5%). Muscle strength increased in 82.8% of the studies (29/35 RCTs) following exercise intervention, and dietary supplementation showed additional benefits in only a small number of studies (8/35 RCTS, 22.8%). Finally, the majority of studies showed an increase of physical performance following exercise intervention (26/28 RCTs, 92.8%) but interaction with nutrition supplementation was only found in 14.3% of these studies (4/28 RCTs). Conclusion: Physical exercise has a positive impact on muscle mass and muscle function in healthy subjects aged 60?years and older. The biggest effect of exercise intervention, of any type, has been seen on physical performance (gait speed, chair rising test, balance, SPPB test, etc.). We observed huge variations in regard to the dietary supplementation protocols. Based on the included studies, mainly performed on well-nourished subjects, the interactive effect of dietary supplementation on muscle function appears limited. ? 2017, The Author(s).
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014076210&doi=10.1007%2fs00198-017-3980-9&partnerID=40&md5=262ed838cb0a016b91ea436f5fb4683a
https://scholars.lib.ntu.edu.tw/handle/123456789/522963
ISSN: 0937-941X
DOI: 10.1007/s00198-017-3980-9
SDG/Keyword: beta hydroxy beta methylbutyrate; butyric acid derivative; creatine; essential amino acid; unclassified drug; vitamin D; beta-hydroxyisovaleric acid; creatine; essential amino acid; valeric acid derivative; vitamin D; aged; diet supplementation; exercise; human; muscle function; muscle mass; muscle strength; nutrient; nutrition; physical activity; physical performance; priority journal; randomized controlled trial (topic); Review; sarcopenia; systematic review; dietary supplement; kinesiotherapy; pathophysiology; physiology; procedures; protein intake; sarcopenia; therapeutic use; Amino Acids, Essential; Creatine; Dietary Proteins; Dietary Supplements; Exercise; Exercise Therapy; Humans; Muscle Strength; Sarcopenia; Valerates; Vitamin D
[SDGs]SDG3
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