https://scholars.lib.ntu.edu.tw/handle/123456789/523048
Title: | Association between Secreted Phosphoprotein-1 (SPP1) polymorphisms and low bone mineral density in women | Authors: | JEN-HAU CHEN YEN-CHING CHEN Mao C.-L. Chiou J.-M. Tsao C.K. KEH-SUNG TSAI |
Issue Date: | 2014 | Publisher: | Public Library of Science | Journal Volume: | 9 | Journal Issue: | 5 | Start page/Pages: | e97428 | Source: | PLoS ONE | Abstract: | Background: A recent meta-analysis found that secreted phosphoprotein-1 (SPP1) can predict the risk of both osteoporosis and fracture. No study has explored the association of SPP1 haplotype-tagging single nucleotide polymorphisms (htSNPs) and haplotypes with bone mineral density (BMD). Methods: This is a cross-sectional study. A total of 1,313 healthy Taiwanese women aged 40 to 55 years were recruited from MJ Health Management Institute from 2009 to 2010. BMD was dichotomized into high and low BMD groups. Three common (allele frequency ?5%) htSNPs were selected to examine the association between sequence variants of SPP1 and BMD. Results: Homozygosity for the T allele of rs4754 were protective from low BMD [TT vs. CC: adjusted OR (AOR) = 0.58, 95% confidence interval (CI) = 0.83-0.89]. A protective effect was also found for women carrying 2 copies of Hap3 TCT (AOR = 0.57, 95% CI = 0.34-0.95). Menopausal status marginally interacted with SPP1 rs6839524 on BMD (p = 0.049). Postmenopausal women carrying variant rs6839524 (GG+GC vs. CC: AOR = 2.35, 95% CI = 1.06-5.20) or Hap1 TGC (AOR = 2.36, 95% CI = 1.06-5.24) were associated with 2.4-fold risk of low BMD. For women with low BMI (<18.5 kg/m 2), variant rs6839524 (AOR = 7.64) and Hap1 (AOR = 6.42) were associated with increased risk of low BMD. These findings did not reach statistical significance after correction for multiple tests. Conclusions: SPP1 htSNP protected against low BMD in middle-aged women. SPP1 genetic markers may be important for the prediction of osteoporosis at an early age. ? 2014 Chen et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901306522&doi=10.1371%2fjournal.pone.0097428&partnerID=40&md5=074e08fa23a99f333c5f33da2720f239 https://scholars.lib.ntu.edu.tw/handle/123456789/523048 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0097428 | SDG/Keyword: | osteopontin; osteopontin; SPP1 protein, human; adult; allele; article; body mass; bone density; cross-sectional study; female; gene frequency; genetic marker; haplotype; homozygosity; human; normal human; osteoporosis; postmenopause; prediction; risk factor; single nucleotide polymorphism; SPP1 gene; Taiwan; bone density; genetic polymorphism; genetics; homozygote; menopause; metabolism; middle aged; questionnaire; Adult; Alleles; Body Mass Index; Bone Density; Cross-Sectional Studies; Female; Haplotypes; Homozygote; Humans; Menopause; Middle Aged; Osteopontin; Osteoporosis; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Questionnaires; Taiwan [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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