https://scholars.lib.ntu.edu.tw/handle/123456789/523110
標題: | Cardiac Autonomic Alteration and Metabolic Syndrome: An Ambulatory ECG-based Study in A General Population | 作者: | Yan Ma PING-HUEI TSENG Andrew Ahn MING-SHIANG WU YI-LWUN HO MING-FONG CHEN Chung-Kang Peng |
公開日期: | 14-三月-2017 | 出版社: | Nature Publishing Group | 卷: | 7 | 起(迄)頁: | 44363 | 來源出版物: | Scientific Reports | 摘要: | Metabolic syndrome (MetS) has been associated with chronic damage to the cardiovascular system. This study aimed to evaluate early stage cardiac autonomic dysfunction with electrocardiography (ECG)-based measures in MetS subjects. During 2012-2013, 175 subjects with MetS and 226 healthy controls underwent ECG recordings of at least 4 hours starting in the morning with ambulatory one-lead ECG monitors. MetS was diagnosed using the criteria defined in the Adult Treatment Panel III, with a modification of waist circumference for Asians. Conventional heart rate variability (HRV) analysis, and complexity index (CI 1-20) calculated from 20 scales of entropy (multiscale entropy, MSE), were compared between subjects with MetS and controls. Compared with the healthy controls, subjects with MetS had significantly reduced HRV, including SDNN and pNN20 in time domain, VLF, LF and HF in frequency domain, as well as SD2 in Poincar? analysis. MetS subjects have significantly lower complexity index (CI 1-20) than healthy subjects (1.69 ± 0.18 vs. 1.77 ± 0.12, p < 0.001). MetS severity was inversely associated with the CI 1-20 (r = ? 0.27, p < 0.001). MetS is associated with significant alterations in heart rate dynamics, including HRV and complexity. ? The Author(s) 2017. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015311766&doi=10.1038%2fsrep44363&partnerID=40&md5=ed92a4c733ffaa22dd9371541d7b8198 https://scholars.lib.ntu.edu.tw/handle/123456789/523110 https://pubmed.ncbi.nlm.nih.gov/28290487/ |
ISSN: | 2045-2322 | DOI: | 10.1038/srep44363 | SDG/關鍵字: | adult; ambulatory electrocardiography; autonomic nervous system; cardiovascular system; case control study; diagnostic imaging; entropy; female; heart; heart rate; human; male; metabolic syndrome X; middle aged; pathophysiology; retrospective study; waist circumference; Adult; Autonomic Nervous System; Cardiovascular System; Case-Control Studies; Electrocardiography, Ambulatory; Entropy; Female; Heart; Heart Rate; Humans; Male; Metabolic Syndrome; Middle Aged; Retrospective Studies; Waist Circumference |
顯示於: | 醫學系 |
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