https://scholars.lib.ntu.edu.tw/handle/123456789/523390
標題: | Usefulness of drug eluting stent in percutaneous coronary intervention - A single center experience in Taiwan | 作者: | HWANG, JUEY-JEN Hsu C.-N. CHI-SHENG HUNG YEN-HUNG LIN HSIEN-LI KAO FU-TIEN CHIANG CHIA-LUN CHAO CHII-MING LEE TZUNG-DAU WANG Liau C.-S. Hsu K.-L. Lin, Lung-Chun CHIA-TI TSAI Tseng C.-D. |
公開日期: | 2007 | 出版社: | Scientific Communications International Ltd | 卷: | 106 | 期: | 8 | 起(迄)頁: | 624-630 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: Drug eluting stents (DES) have been shown to reduce in-stent restenosis rate and target vessel revascularization in large clinical trials. However, the safety and efficacy of DES use in the Taiwanese population has not been reported. We designed this trial to analyze the clinical results in patients using DES in a single tertiary center. Methods: We retrospectively analyzed the clinical data of all patients treated at National Taiwan University Hospital, Taipei, Taiwan, with sirolimus- or paclitaxel-eluting stents between September 2003 and January 2005. Results: A total of 585 patients (466 men, 119 women; mean age, 64.5 ± 11.2 years) were enrolled: Meanwhile, 205 sirolimus- and 717 paclitaxel-eluting stents were implanted, with a mean of 1.6 stents per patient. Half (50.2%) of the stents were placed in the left anterior descending artery. Among the enrolled patients, 41.8% had diabetes mellitus, 25% had a diagnosis of acute coronary syndrome, and 10.7% was treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Overall 8-month target vessel revascularization, major adverse cardiac event rate, and cardiac death rate were 8.8%, 9.7% and 2.5%, respectively. There was no difference in clinical events between sirolimus- and paclitaxel-eluting stents. The overall subacute stent thrombosis rate was 1.36%, significantly lower than that in patients who presented with acute coronary syndrome (4%). Conclusion: The use of DES in the Taiwanese population yielded comparable results as those in large clinical trials. Subacute stent thrombosis rate was higher in acute coronary syndrome. The safety of DES in these situations should be further clarified. ? 2007 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34548493482&doi=10.1016%2fS0929-6646%2808%2960019-4&partnerID=40&md5=d661e07ccead1306172b4e667da74d15 https://scholars.lib.ntu.edu.tw/handle/123456789/523390 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(08)60019-4 | SDG/關鍵字: | acetylsalicylic acid; clopidogrel; fibrinogen receptor antagonist; heparin; paclitaxel; rapamycin; acute coronary syndrome; adult; adverse outcome; aged; artery thrombosis; article; controlled study; diabetes mellitus; drug eluting stent; female; heart death; heart infarction; heart muscle revascularization; human; implantation; left anterior descending coronary artery; major clinical study; male; percutaneous coronary intervention; retrospective study; ST segment elevation; Taiwan |
顯示於: | 醫學系 |
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