https://scholars.lib.ntu.edu.tw/handle/123456789/523428| Title: | Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women | Authors: | Wong J.Y.Y. Zhang H Hsiung C.A. Shiraishi K. Yu K. Matsuo K. Wong M.P. Hong Y.-C. Wang J. Seow W.J. Wang Z. Pang H. Li Y. Choi J.E. Park K.H. Sung S.W. Liu L. Kang C.H. Zhu M. Chen C.-H. Yang T.-Y. Song M. Xu J. Guan P. Tan W. Wang C.-L. Hsin M. Sit K.-Y. Ho J. Chen Y. Choi Y.Y. Hung J.-Y. Kim H.N. Kim J.S. Yoon H.I. Lin C.-C. Park I.K. Xu P. Wang Y. He Q. Perng R.-P. Chen C.-Y. Vermeulen R. Chang I.-S. Wu J. Lim W.-Y. Chen K.-C. Li Y.-J. Li J. Chen H. CHONG-JEN YU Jin L. Chen T.-Y. Jiang S.-S. Chatterjee N. Liu J. Yamaji T. Hicks B. Wyatt K. Li S.A. Dai J. Ma H. Jin G. Song B. Wang Z. Hu W. Cheng S. Li X. Ren Y. Cui P. Iwasaki M. Shimazu T. Tsugane S. Zhu J. Yang K. Jiang G. Wu C. Fei K. Wu G. Lin H.-C. Chen H.-L. Fang Y.-H. Tsai F.-Y. Hsieh W.-S. Yu J. Stevens V.L. Laird-Offringa I.A. Mitsudomi T. Marconett C.N. Rieswijk L. Chao A. PAN-CHYR YANG Shu X.-O. Wu T. Wu Y.L. Lin D. Chen K. Zhou B. Zheng W. Huang Y.-C. Kohno T. Shen H. Chanock S.J. Rothman N. Lan Q. Kim J.H. Seow A. Caporaso N.E. Shin M.-H. Chung L.P. An S.-J. Wang P. Yang Y. Zheng H. Yatabe Y. Zhang X.-C. Kim Y.T. Cai Q. Yin Z. Kim Y.-C. Bassig B.A. Chang J. Ho J.C.M. Ji B.-T. Daigo Y. Ito H. Momozawa Y. Ashikawa K. Kamatani Y. Honda T. Hosgood H.D. Sakamoto H. Kunitoh H. Tsuta K. Watanabe S.-I. Kubo M. Miyagi Y. Nakayama H. Matsumoto S. Tsuboi M. Goto K. Shi J. Song L. Hua X. Takahashi A. Goto A. Minamiya Y. Shimizu K. Tanaka K. Wei F. Matsuda F. Su J. Kim Y.H. Oh I.-J. Song F. Su W.-C. Chen Y.-M. Chang G.-C. KUAN-YU CHEN Huang M.-S. Chien L.-H. Xiang Y.-B. Park J.Y. Kweon S.-S. Chen C.-J. Lee K.-M. Blechter B. Li H. Gao Y.-T. Qian B. Lu D. Liu J. Jeon H.-S. Hsiao C.-F. Sung J.S. Tsai Y.-H. Jung Y.J. Guo H. Hu Z. Wang W.-C. Chung C.C. Burdett L. Yeager M. Hutchinson A. Berndt S.I. Wu W. |
Issue Date: | 2020 | Publisher: | Academic Press Inc. | Journal Volume: | 112 | Journal Issue: | 2 | Start page/Pages: | 1223-1232 | Source: | Genomics | Abstract: | We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women. ? 2019 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068966697&doi=10.1016%2fj.ygeno.2019.07.008&partnerID=40&md5=2f03da81363ca97dba6e57d733f19b1b https://scholars.lib.ntu.edu.tw/handle/123456789/523428 |
ISSN: | 0888-7543 | DOI: | 10.1016/j.ygeno.2019.07.008 | SDG/Keyword: | HLA DQA1 antigen; adult; Article; controlled study; DLG2 gene; East Asian; female; FHAD1 gene; gene; genetic association; genetic susceptibility; genetic variability; genome-wide association study; HLA DQA1 gene; human; LRRC69 gene; lung adenocarcinoma; major clinical study; MEIS2 gene; Mendelian randomization analysis; never smoker; observational study; pathway analysis; priority journal; single nucleotide polymorphism; statistical analysis; tuberculosis; ZFPM2 gene; Asian continental ancestry group; genetics; lung adenocarcinoma; lung tuberculosis; lung tumor; Adenocarcinoma of Lung; Asian Continental Ancestry Group; Female; Genome-Wide Association Study; Humans; Lung Neoplasms; Mendelian Randomization Analysis; Non-Smokers; Tuberculosis, Pulmonary [SDGs]SDG3 |
| Appears in Collections: | 醫學系 |
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