https://scholars.lib.ntu.edu.tw/handle/123456789/523431
標題: | Precision Management of Advanced Non-Small Cell Lung Cancer | 作者: | CHING-YAO YANG CHIH-HSIN YANG PAN-CHYR YANG |
公開日期: | 2020 | 出版社: | Annual Reviews Inc. | 卷: | 71 | 起(迄)頁: | 117-136 | 來源出版物: | Annual Review of Medicine | 摘要: | The rapid evolution of treatment for advanced lung cancer is a story of how scientists have struggled to move from nonselective cytotoxic chemotherapy to personalized precision medicine. In this century, extraordinary advances have been made in the management of advanced and metastatic non-small cell lung cancer, especially in the development of small molecules targeting specific tyrosine kinase receptors and immune checkpoint inhibitors. These developments have led to a significant improvement in survival for lung cancer patients with metastatic disease. Now, the core guidelines to treat non-small cell lung cancer are based on the identification of targetable driver mutations and immune checkpoints. Continued investigations of newly identified druggable genetic alterations, explorations of biomarkers of immune checkpoint inhibitors, development of next-generation immunotherapy, and optimization of combination therapy are necessary to provide better treatment outcomes for lung cancer patients in the future. ? 2020 by Annual Reviews. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078406929&doi=10.1146%2fannurev-med-051718-013524&partnerID=40&md5=e2308d337f1fe3f69ce5dcb80b32f1f9 https://scholars.lib.ntu.edu.tw/handle/123456789/523431 |
ISSN: | 0066-4219 | DOI: | 10.1146/annurev-med-051718-013524 | SDG/關鍵字: | anaplastic lymphoma kinase; antineoplastic agent; B Raf kinase; epidermal growth factor receptor; immune checkpoint inhibitor; immunological antineoplastic agent; unclassified drug; anaplastic lymphoma kinase; angiogenesis inhibitor; B Raf kinase; epidermal growth factor receptor; programmed death 1 ligand 1; programmed death 1 receptor; protein kinase inhibitor; advanced cancer; c ros1 oncogene; cancer immunotherapy; cancer prognosis; cancer survival; gene mutation; human; lung adenocarcinoma; molecularly targeted therapy; non small cell lung cancer; oncogene; personalized medicine; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); priority journal; randomized controlled trial (topic); Review; genetics; lung adenocarcinoma; lung tumor; non small cell lung cancer; personalized medicine; squamous cell carcinoma; Adenocarcinoma of Lung; Anaplastic Lymphoma Kinase; Angiogenesis Inhibitors; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; ErbB Receptors; Humans; Lung Neoplasms; Molecular Targeted Therapy; Precision Medicine; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf |
顯示於: | 醫學系 |
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