https://scholars.lib.ntu.edu.tw/handle/123456789/523496
標題: | EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma | 作者: | Chen H.-Y. Liu C.-H. Chang Y.-H. SUNG-LIANG YU Ho B.C. Hsu C.-P. Yang T.-Y. Chen K.-C. Hsu K.-H. Tseng J.-S. Hsia J.-Y. Chuang C.-Y. Chang C.-S. Li Y.-C. Li K.-C. Chang G.-C. PAN-CHYR YANG |
公開日期: | 2016 | 出版社: | Impact Journals LLC | 卷: | 7 | 期: | 8 | 起(迄)頁: | 9017-9025 | 來源出版物: | Oncotarget | 摘要: | In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. In the stratification analysis, only ERBB2 showed significant discrepancy in patients carrying wild type EGFR and other members of ErbB family in patients carrying EGFR-activating mutation. This indicated that CNAs of ErbB family had effect modifications of EGFR-activating mutation status. Findings of this study demonstrate potential molecular guidance of patient management of lung adenocarcinoma with or without EGFR-activating mutations. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961602243&doi=10.18632%2foncotarget.7029&partnerID=40&md5=e074641c58ac4da72a8493a7e3233814 https://scholars.lib.ntu.edu.tw/handle/123456789/523496 |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.7029 | SDG/關鍵字: | epidermal growth factor receptor; epidermal growth factor receptor 2; epidermal growth factor receptor 3; epidermal growth factor receptor 4; EGFR protein, human; epidermal growth factor receptor; epidermal growth factor receptor 2; epidermal growth factor receptor 3; epidermal growth factor receptor 4; ERBB2 protein, human; ERBB3 protein, human; ERBB4 protein, human; Article; cancer prognosis; cancer survival; controlled study; disease association; exon; female; gene deletion; gene dosage; gene mutation; genetic association; human; human tissue; lung adenocarcinoma; male; mutational analysis; overall survival; survival prediction; wild type; adenocarcinoma; enzyme activation; gene dosage; genetics; lung tumor; metabolism; mortality; pathology; Adenocarcinoma; Enzyme Activation; Female; Gene Dosage; Humans; Lung Neoplasms; Male; Receptor, Epidermal Growth Factor; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4 |
顯示於: | 醫學系 |
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